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Official Full Name kinesin family member 5A
Background This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.
Synonyms KIF5A; kinesin family member 5A; spastic paraplegia 10 (autosomal dominant) , SPG10; kinesin heavy chain isoform 5A; D12S1889; MY050; NKHC; KIF5A variant protein; neuronal kinesin heavy chain; kinesin heavy chain neuron-specific 1; kinesin, heavy chain, n
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KIF5A-259H Recombinant Human KIF5A Protein, His-tagged E.coli His
    Human KIF5A-376H Recombinant Human KIF5A, GST-tagged E.coli GST
    Mouse Kif5a-260M Recombinant Mouse Kif5a Protein, His/GST-tagged E.coli His/GST
    Mouse KIF5A-8647M Recombinant Mouse KIF5A Protein Mammalian Cell His
    Rat Kif5a-261R Recombinant Rat Kif5a Protein, His/GST-tagged E.coli His/GST
    Rat KIF5A-3258R Recombinant Rat KIF5A Protein Mammalian Cell His

    kif5a involved in several pathways and played different roles in them. We selected most pathways kif5a participated on our site, such as Adaptive Immune System, Dopaminergic synapse, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with kif5a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System RBCK1; PDPK1A; AGO3; SIGLEC5; KLHL21; SIGLEC11; UBR1; CTSC; CD200; IFI30
    Dopaminergic synapse PPP2R2A; GNAI2; AKT2; ARNTL; PLCB3; PPP2R2C; PPP1CA; GNAS; PPP2R3C; PPP2R5D
    Factors involved in megakaryocyte development and platelet production KIF26A; GATA6; H3F3B.1; KIF11; VPS45; MYB; KIF18A; GATA1; DOCK11; MAFG
    Hemostasis CBX5; NADL1.1; EHD1; FN1B; WDR1; GATA5; STXBP3; CD9B; KIF20A; IRF2A
    Immune System CFHL1; LILRB5; RIPK3; IgG3; AP1B1; CFD; CFHL4; DCTN3; IFIT11; MGC174155
    Insulin processing CPE; EXOC3; KIF5B; EXOC1; PCSK2; EXOC6; SLC30A6; RAB27A; SLC30A5; EXOC5
    Kinesins KIF26A; KIF5A; KIF4; KIF2C; KIF15; KIF9; KIF4A; CENPE; KIF18A; KIFAP3

    kif5a has several biochemical functions, for example, ATP binding, ATP-dependent microtubule motor activity, plus-end-directed, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by kif5a itself. We selected most functions kif5a had, and list some proteins which have the same functions with kif5a. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TRPV1; ATP2A2; PKN2; HSPA13; UBE2B; UBE2I; PKN3; MSH3; MELK; DNAJA3B
    ATP-dependent microtubule motor activity, plus-end-directed KIF5C; KIF3B; KIF5AA; KIF5B; KIF14; KIF18B; KIF16B; KIF19; KIF1C; KIF1B
    microtubule binding TUBGCP5; JAKMIP3; CRIPT; NDEL1B; MTUS2; KIF20A; REEP1; S100A9; EZR; KIF11
    motor activity SMYHC2; DYNC1I1; MYO1F; MYO6B; DYNLL2; MYO15; MYO1E; VMHC; MYO1H; MYL6B
    protein binding TTC12; APPL2; SCGB2A2; ARL11; CLEC4G; POLR1D; DNAJC5B; TNIP3; REV1; SLC30A8

    kif5a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kif5a here. Most of them are supplied by our site. Hope this information will be useful for your research of kif5a.

    ANKRD27; RXRB; PCBD1; MDM2; Trak2; TRAK1; MAP4K4; TK1; Hap1; PIN1; TP53BP2; ITSN1; SMN1; TRAF3IP1; M

    Uchida, A; Alami, NH; et al. Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments. MOLECULAR BIOLOGY OF THE CELL 20:4997-5006(2009).
    van der Linden, MPM; Feitsma, AL; et al. Association of a Single-Nucleotide Polymorphism in CD40 With the Rate of Joint Destruction in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 60:2242-2247(2009).

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