KIF5A

  • Official Full Name

    kinesin family member 5A
  • Overview

    This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.
  • Synonyms

    KIF5A;kinesin family member 5A;spastic paraplegia 10 (autosomal dominant) , SPG10;kinesin heavy chain isoform 5A;D12S1889;MY050;NKHC;KIF5A variant protein;neuronal kinesin heavy chain;kinesin heavy chain neuron-specific 1;kinesin, heavy chain, n

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
KIF5A-376H Recombinant Human KIF5A, GST-tagged E.coli Human GST C-102aa
KIF5A-259H Recombinant Human KIF5A Protein, His-tagged E.coli Human His Leu473~Cys605
Kif5a-260M Recombinant Mouse Kif5a Protein, His/GST-tagged E.coli Mouse GST&His Ala2~Ile211
Kif5a-261R Recombinant Rat Kif5a Protein, His/GST-tagged E.coli Rat GST&His Ile823~Ser1027
KIF5A-3258R Recombinant Rat KIF5A Protein Mammalian Cells Rat His
KIF5A-8647M Recombinant Mouse KIF5A Protein Mammalian Cells Mouse His
KIF5A-2361H Recombinant Human KIF5A Protein, His-tagged E.coli Human His Val174-Lys315
KIF5A-2914R Recombinant Rat KIF5A Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KIF5A-2914R-B Recombinant Rat KIF5A Protein Pre-coupled Magnetic Beads HEK293 Rat
KIF5A-4819M Recombinant Mouse KIF5A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KIF5A-4819M-B Recombinant Mouse KIF5A Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KIF5A involved in several pathways and played different roles in them. We selected most pathways KIF5A participated on our site, such as Adaptive Immune System,Dopaminergic synapse,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dopaminergic synapse PPP2R2D,GNG11,AKT1,CREB3,CAMK2A,KIF5B,GRIA1,CREB5,GSK3A,MAPK13
    Immune System NLRP4B,PRLRB,ARIH2,DEFB129,UBE2U,DDOST,IFITM3,SH3RF1,CFHL2,TRIM14
    Kinesins KIF2C,KIF11,KIF3C,KIF4A,KLC3,KIF9,KIF22,CENPE,KIF15,KIFC1
    Insulin processing CPE,EXOC1,SLC30A5,RAB27A,CPN1,EXOC5,EXOC8,PCSK1,EXOC3,EXOC6
    Endocytosis HLA-C,ASAP1,TGFBR1A,VPS25,CLTCB,IST1,HLA-G,EHD1,RLN1,IL2RGA
    Factors involved in megakaryocyte development and platelet production HMG20B,DOCK8,GATA1,H3F3B.1,OSTN,MAFGA,MAFF,NFE2,EHD1,ZFPM2A
    Adaptive Immune System KIF4,ARF1,RNF182,BLMH,KIF26A,SPTBN2,KLRB1F,ASB10,CD300LF,FBXO17
    Hemostasis ANXA2B,D-AKAP2,HBG2,KIF11,DOCK9,ESAMA,GATA5,ITPK1,NADL1.1,KIFC1

    Protein Function

    KIF5A has several biochemical functions, for example, ATP binding,ATP-dependent microtubule motor activity, plus-end-directed,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF5A itself. We selected most functions KIF5A had, and list some proteins which have the same functions with KIF5A. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CMPK2,GSS,PRKCHB,RAD51C,UBE2L3,NEK2,ENTPD2,NADK2,RPS6KAL,ABCA1
    protein binding MALT1,SMURF2,ZFP36L1,STK3,SUB1,CTNND1,AGBL4,MRAP2,FANCD2,IMPA1
    motor activity MYH9,DCTN2,MYH15,CGNL1,MYO1F,MYO7AA,SMYHC1,VMHCL,DNAIC2,VMHC
    ATP-dependent microtubule motor activity, plus-end-directed KIF17,KIF14,KIF18B,KIF18A,KIF11,KIF5B,KIF3A,KIF1C,KIF20B,KIF5AA
    microtubule binding KIF5B,KIF12,CLASP1,RPS3,NEFH,CEP57L1,KIF7,SBDS,GCAP14,CHD4A

    Interacting Protein

    KIF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF5A.

    ANKRD27;RXRB;PCBD1;MDM2;Trak2;TRAK1;MAP4K4;TK1;Hap1;PIN1;TP53BP2;ITSN1;SMN1;TRAF3IP1;M

    Resources

    References

    • Uchida, A; Alami, NH; et al. Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments. MOLECULAR BIOLOGY OF THE CELL 20:4997-5006(2009).
    • van der Linden, MPM; Feitsma, AL; et al. Association of a Single-Nucleotide Polymorphism in CD40 With the Rate of Joint Destruction in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 60:2242-2247(2009).

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