KIF5A
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Official Full Name
kinesin family member 5A -
Overview
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. -
Synonyms
KIF5A;kinesin family member 5A;spastic paraplegia 10 (autosomal dominant) , SPG10;kinesin heavy chain isoform 5A;D12S1889;MY050;NKHC;KIF5A variant protein;neuronal kinesin heavy chain;kinesin heavy chain neuron-specific 1;kinesin, heavy chain, n
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIF5A-376H | Recombinant Human KIF5A, GST-tagged | E.coli | Human | GST | C-102aa | |
| KIF5A-259H | Recombinant Human KIF5A Protein, His-tagged | E.coli | Human | His | Leu473~Cys605 | |
| Kif5a-260M | Recombinant Mouse Kif5a Protein, His/GST-tagged | E.coli | Mouse | GST&His | Ala2~Ile211 | |
| Kif5a-261R | Recombinant Rat Kif5a Protein, His/GST-tagged | E.coli | Rat | GST&His | Ile823~Ser1027 | |
| KIF5A-3258R | Recombinant Rat KIF5A Protein | Mammalian Cells | Rat | His |
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| KIF5A-8647M | Recombinant Mouse KIF5A Protein | Mammalian Cells | Mouse | His |
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| KIF5A-2361H | Recombinant Human KIF5A Protein, His-tagged | E.coli | Human | His | Val174-Lys315 |
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| KIF5A-2914R | Recombinant Rat KIF5A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| KIF5A-2914R-B | Recombinant Rat KIF5A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KIF5A-4819M | Recombinant Mouse KIF5A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| KIF5A-4819M-B | Recombinant Mouse KIF5A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KIF5A involved in several pathways and played different roles in them. We selected most pathways KIF5A participated on our site, such as Adaptive Immune System,Dopaminergic synapse,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Kinesins | KIFC1,KIF11,KIF26A,KIF15,KIF9,KIF18A,KIF2B,KIF3B,RACGAP1,KIF4A |
| Factors involved in megakaryocyte development and platelet production | DOCK9,ITPK1,D-AKAP2,EHD1,HBB-BH1,MAFF,CENPE,HBG2,HBBE1.1,HBE1 |
| Dopaminergic synapse | GRIN2A,MAPK8,GRIN2B,GNG11,MAPK12,MAPK11,PPP2R2A,PPP2R2B,PRKACB,PPP2CB |
| Immune System | CRTAM,IRF4,KLRF1,TRIM29,KIF5B,ASB14,TXNIPA,CTSLL,CD300LD,SPSB2 |
| Insulin processing | CPE,PCSK2,SLC30A8,EXOC6,SLC30A5,KIF5B,SLC30A6,EXOC5,PCSK1,EXOC1 |
| Hemostasis | APOA1B,FN1B,EHD1,SLC3A2B,HBG2,PROCR,SPARC,CD177,D-AKAP2,KIF4 |
| Endocytosis | SNX1,ASAP2B,RAB35,RAB11B,SH3GL3B,PIP5K1C,ASAP2,CAPZA1B,ARRB2,KDRL |
| Adaptive Immune System | PAG1,SPSB1,MGC174152,CTSH,KLRB1F,SIGLEC11,TREML1,LTN1,TRAF7,ASB3 |
Protein Function
KIF5A has several biochemical functions, for example, ATP binding,ATP-dependent microtubule motor activity, plus-end-directed,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF5A itself. We selected most functions KIF5A had, and list some proteins which have the same functions with KIF5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | PRC1A,MAP1S,KATNAL2,SYBU,KIF3CB,CAMSAP1A,KIF13B,CEP350,GOLGA2,SKA2 |
| motor activity | CGNB,MYO6A,VMHC,MYH11A,MYO6B,MYHZ1.1,MYHZ1.2,DYNLRB1,VMHCL,DYNLL1 |
| ATP-dependent microtubule motor activity, plus-end-directed | KIF14,KIF3A,KIF1B,KIF17,KIF5C,KIF16B,KIF1C,KIF18A,KIF19,KIF5B |
| ATP binding | SYN2A,PDK2,SKIV2L,NLRP4E,CSNK2A1,UBE2D4,CSNK1G2A,PCCB,UBE2N,EARS2 |
| protein binding | CUL4A,SLC39A7,PPP2R5B,WLS,DDX20,ACSS1,ABTB1,CERS2,ARNTL1B,MED29 |
Interacting Protein
KIF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF5A.
ANKRD27;RXRB;PCBD1;MDM2;Trak2;TRAK1;MAP4K4;TK1;Hap1;PIN1;TP53BP2;ITSN1;SMN1;TRAF3IP1;M
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References
- Uchida, A; Alami, NH; et al. Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments. MOLECULAR BIOLOGY OF THE CELL 20:4997-5006(2009).
- van der Linden, MPM; Feitsma, AL; et al. Association of a Single-Nucleotide Polymorphism in CD40 With the Rate of Joint Destruction in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 60:2242-2247(2009).
