kif7

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kif7

Official Full Name kinesin family member 7
Background This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.
Synonyms KIF7; kinesin family member 7; kinesin-like protein KIF7; JBTS12; EQYK340; ACLS; HLS2; UNQ340; MGC120653; MGC138476; MGC138478
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KIF7-4943HCL Recombinant Human KIF7 293 Cell Lysate HEK293 N/A
    Mouse KIF7-8651M Recombinant Mouse KIF7 Protein Mammalian Cell His
    Zebrafish KIF7-2286Z Recombinant Zebrafish KIF7 Mammalian Cell His

    kif7 involved in several pathways and played different roles in them. We selected most pathways kif7 participated on our site, such as Hedgehog off state, Hedgehog on state, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with kif7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog off state BBS13; OFD1; INTU; IFT172; IFT122; MKS1; IFT88; TTC21B; GPR161; IFT52
    Hedgehog on state BOC; IFT172; EVC; EFCAB7; IQCE; GAS8; CDC73; KIF7; MKS1; RPGRIP1L
    Signal Transduction BCO2A; INHBAA; OPN1LW2; ARHGAP19; EMR3; RHOT1A; RTN4; ARHGAP22; GPR65; GPR31
    Signaling by Hedgehog KIF7; TULP3; GAS8; EVC2; IFT52; NOTUM; SPOP; CDON; CDC73; WDR35

    kif7 has several biochemical functions, for example, ATP binding, ATPase activity, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by kif7 itself. We selected most functions kif7 had, and list some proteins which have the same functions with kif7. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding BMPR1B; PAK2B; CKMT1; BRAF; Aatk; MAP3K9; SMARCAD1; CLPXA; HSP104; NME2B.2
    ATPase activity ATAD1A; ABCF1; MYH8; MACF1; CARNS1; KIF14; ABCF2; EIF4A1B; WRNIP1; DNAH5
    microtubule binding NDEL1A; FES; CLIP3; RACGAP1; KATNB1; RCC2; NEFH; HDAC6; MAPRE1A; KIF14
    microtubule motor activity KIFC1; KIF3B; KIF25; KIF14; KIFC3; KLC4; KIF3CB; KIF26A; DNAIC2; DNHD1
    protein binding PFDN5; GLRA1; ZYX; ARL14; CTSL1; PID1; SETMAR; ZNF385C; CNBP; PPIH

    kif7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kif7 here. Most of them are supplied by our site. Hope this information will be useful for your research of kif7.

    USP22; EPB41L3; q9wmx2-pro_0000037548; TBC1D31; PCM1; MAP3K4; N4BP3; NRD1; MPZL1; STAMBP; ACTL6A; APC; GMPS; SMTN; HSPG2; PCM1; CCDC18; RAB11FIP2; EMSY

    Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

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