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KIFAP3

Official Full Name

kinesin-associated protein 3
Overview

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 Armadillo repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms

KIFAP3; kinesin-associated protein 3; KAP3; SMAP; Smg GDS; smg GDS-associated protein; small G protein GDP dissociation stimulator; KAP-3; Smg-GDS; dJ190I16.1; FLJ22818;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	KIFAP3-8653M	Recombinant Mouse KIFAP3 Protein	Mammalian Cell	His	Inquiry
Mouse	KIFAP3-4823M	Recombinant Mouse KIFAP3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	KIFAP3-4823M-B	Recombinant Mouse KIFAP3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KIFAP3 Related Articles
KIFAP3 Related Gene Family

KIFAP3 involved in several pathways and played different roles in them. We selected most pathways KIFAP3 participated on our site, such as Adaptive Immune System, Assembly of the primary cilium, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIFAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	ASB3;PIK3AP1;MKRN1;TRIM39;LAIR2;KIF26A;RNF138;ASB10;TREML4
Assembly of the primary cilium	BBS9;FLR;AKAP9;PKD2;IFT27;RABL5;TUBB4A;KIFAP3;EXOC5
Factors involved in megakaryocyte development and platelet production	CENPE;VPS45;MYB;DOCK2;EHD1;H3F3B.1;MFN1;ZFPM2A;IRF1B
Hemostasis	KLC3;CABLES2;AKAP1;GRB7;KIF11;HBB-BH1;RACGAP1;SCG3;DOCK11
Immune System	SLAMF6;IFIT14;MGC174857;TREML4;CRCP;MICA;ABI1A;CFHL3;IRAK3
Intraflagellar transport	KIF3B;WDR34;DYNLL2B;IFT-20;TTC30A2;IFT80;C11orf60;TCTEX1D1;IFT20
Kinesins	KIF2B;RACGAP1;KIF11;KIF20A;KIFC1;KIFAP3;KIF4;KIF3C;KIF5A
MHC class II antigen presentation	KIF26A;KLC3;CTSH;DCTN6;CTSE;CTSLL;RACGAP1;MGC174155;ACTR1B

KIFAP3 has several biochemical functions, for example, kinesin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIFAP3 itself. We selected most functions KIFAP3 had, and list some proteins which have the same functions with KIFAP3. You can find most of the proteins on our site.

Function	Related Protein
kinesin binding	CD36;KLC3;ATCAY;JIP1;CLSTN1;MAPK8IP3;PIFO;ARPC2;PLEKHM2
protein binding	XAGE3;LINC01588;TUT1;LAMA1;GRB10;CTDSP2;MTA2;ZC3H18;TIMM10

KIFAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIFAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIFAP3.

Kif3a; VHL; Sptan1; Vhl; Ank2

Khodjakov, A; Lizunova, EM; et al. A specific light chain of kinesin associates with mitochondria in cultured cells. MOLECULAR BIOLOGY OF THE CELL 9:333-343(1998).