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KLF2

Official Full Name

Kruppel-like factor 2 (lung)
Overview

Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell;trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L;(SELL; MIM 153240) (summary by Weinreich et al., 2009 (PubMed 19592277)).
Synonyms

KLF2; Kruppel-like factor 2 (lung); Krueppel-like factor 2; LKLF; KLF 2; KLF2_HUMAN; Kruppel like factor 2; Kruppel like factor; Kruppel like factor LKLF; Lung krueppel like factor; Lung krueppel-like factor; Lung Kruppel like zinc finger transcription factor; Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription factor;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
HEK293T
Mamanlian cells
Mammalian Cell

Tag

Flag
His
His (Fc)
Avi
MYC
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	KLF2-185H	Recombinant Human KLF2 protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	KLF2-4928H	Recombinant Human KLF2 protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	KLF2-4928HCL	Recombinant Human KLF2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	KLF2-7418HFL	Recombinant Full Length Human KLF2 protein, Flag-tagged	Mamanlian cells	Flag	Inquiry
Mouse	Klf2-1275M	Recombinant Mouse Klf2 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK	Inquiry
Rat	KLF2-3271R	Recombinant Rat KLF2 Protein	Mammalian Cell	His	Inquiry
Rat	KLF2-2927R-B	Recombinant Rat KLF2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	KLF2-2927R	Recombinant Rat KLF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

KLF2 involved in several pathways and played different roles in them. We selected most pathways KLF2 participated on our site, such as FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO signaling pathway	PIK3CA;Fasl;FOXO4;PIK3R3;FOXO3;FOXO3B;SGK3;PLK4;TGFBR1A

KLF2 has several biochemical functions, for example, metal ion binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF2 itself. We selected most functions KLF2 had, and list some proteins which have the same functions with KLF2. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	GALNTL5;SPNA1;KLF2;SCRT2;B4GALT2;HIC1;POGZ;BTR16;CA14
protein binding	ANO6;PSRC1;FCER2;YY1;CENPL;PDE4D;WDR18;VPS24;PFKFB2
sequence-specific DNA binding	HOXA11A;TCF7L1A;RXRGB;HOXB2;ENG1A;HOXB6A;SP1;FOXF2;VDRA
transcription factor activity, sequence-specific DNA binding	ZFP30;BHLHE40;ATF2;EOMES;BCL3;PA2G4;RFXANK;TBX10;KDM5B

KLF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF2.

SMURF1; SMURF1

Research Area

Intracellular Signaling Molecules in Angiogenesis

Transcription Regulators in Endothelial Cells

Transcription Regulators in VSMC

Pluripotent Stem Cell Transcription Factors

Ware, CB; Nelson, AM; et al. Derivation of naive human embryonic stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4484-4489(2014).

Allen, KL; Jain, MK; et al. KLF2 and KLF4 Are Essential Mediators of the Anti-Thrombotic Effects of Statins in the Presence of Antiphospholipid/Anti-beta(2)GPI Antibodies. BLOOD 118:1407-1407(2011).