KLF2

  • Official Full Name

    Kruppel-like factor 2 (lung)

  • Overview

    Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell;trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L;(SELL; MIM 153240) (summary by Weinreich et al., 2009 (PubMed 19592277)).
  • Synonyms

    KLF2; Kruppel-like factor 2 (lung); Krueppel-like factor 2; LKLF; KLF 2; KLF2_HUMAN; Kruppel like factor 2; Kruppel like factor; Kruppel like factor LKLF; Lung krueppel like factor; Lung krueppel-like factor; Lung Kruppel like zinc finger transcription factor; Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLF2-185H Recombinant Human KLF2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human KLF2-4928H Recombinant Human KLF2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human KLF2-4928HCL Recombinant Human KLF2 293 Cell Lysate HEK293 N/A
Human KLF2-7418HFL Recombinant Full Length Human KLF2 protein, Flag-tagged Mamanlian cells Flag
Mouse Klf2-1275M Recombinant Mouse Klf2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat KLF2-3271R Recombinant Rat KLF2 Protein Mammalian Cell His
Rat KLF2-2927R-B Recombinant Rat KLF2 Protein Pre-coupled Magnetic Beads HEK293
Rat KLF2-2927R Recombinant Rat KLF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KLF2 Related Articles
  • KLF2 Related Research Area

KLF2 involved in several pathways and played different roles in them. We selected most pathways KLF2 participated on our site, such as FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayARAF;IGF1RB;SGK3;TNFSF10;PRKAB1A;INS;PIK3CG;INSR;TGFBR2

KLF2 has several biochemical functions, for example, metal ion binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF2 itself. We selected most functions KLF2 had, and list some proteins which have the same functions with KLF2. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingMETAP2A;ZNF580;PPP1CB;ZNF695;COL5A1;IRGF4;RASSF5;PPARAA;USP19
protein bindingSOST;NCAPH2;PRICKLE1A;BCLAF1;MECOM;EIF3J;NLGN4X;Chrng;BYSL
sequence-specific DNA bindingNFYBB;SIX1;NKX2.1;CALCOCO1;FOXD1L;ENG2B;HLFB;MAFK;SNAI2
transcription factor activity, sequence-specific DNA bindingNPAS2;TBX22;PRDM15;CREB3L3A;ETV1;NFIA;HOMEZ;ZFP110;ZFP13

KLF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF2.

SMURF1; SMURF1

Ware, CB; Nelson, AM; et al. Derivation of naive human embryonic stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4484-4489(2014).
Allen, KL; Jain, MK; et al. KLF2 and KLF4 Are Essential Mediators of the Anti-Thrombotic Effects of Statins in the Presence of Antiphospholipid/Anti-beta(2)GPI Antibodies. BLOOD 118:1407-1407(2011).
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