LAIR1

  • Official Full Name

    leukocyte-associated immunoglobulin-like receptor 1

  • Overview

    The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
  • Synonyms

    LAIR1; leukocyte-associated immunoglobulin-like receptor 1; leukocyte associated Ig like receptor 1; CD305; 5133400O11Rik; D7Bwg0421e; hLAIR1; LAIR 1; LAIR-1; LAIR1 protein; LAIR1_HUMAN; Leukocyte associated immunoglobulin like receptor 1; OTTHUMP00000068183; OTTHUMP00000068184; OTTHUMP00000068185; OTTHUMP00000068186; OTTHUMP00000068187; leukocyte-associated Ig-like receptor 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus macaque
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • Avi
  • hFc
  • hIgG1
  • hIgG4
  • His (Fc)
  • human|IgG1|Fc
  • mFc
  • Mouse|IgG|Fc
  • Mouse|IgG2a|Fc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LAIR1-061H Active Recombinant Human LAIR1 protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Gln22-His163
Human LAIR1-29001TH Recombinant Human LAIR1 E.coli N/A
Human LAIR1-624H Recombinant Human LAIR1 Mammalian Cell His
Human LAIR1-525H Recombinant Human LAIR1 protein, hFc-tagged HEK293 hFc Met1-Tyr165
Human LAIR1-350H Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 1 E.coli N/A
Human LAIR1-524H Recombinant Human LAIR1 Protein, His-tagged HEK293 His
Human LAIR1-348H Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 1, His-tagged E.coli His
Human LAIR1-377H Recombinant Human LAIR1 protein, Fc-tagged HEK293 human/IgG1/Fc 142
Human LAIR1-091H Recombinant Human LAIR1 Protein, His-tagged E.coli His
Human LAIR1-382H Recombinant Human LAIR1 protein, His-tagged HEK293 His 142
Human LAIR1-3325H Recombinant Human LAIR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LAIR1-068H Recombinant Human LAIR1 protein, His-Avi-tagged HEK293 His-Avi Gln22-His163
Human LAIR1-0350H Active Recombinant Human LAIR1 protein, Fc-tagged HEK293 Fc Gln22-His163
Human LAIR1-378H Recombinant Human LAIR1(Gln22-His163) Protein, C-mFc-tagged HEK293 mFc
Human LAIR1-166H Recombinant Human LAIR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LAIR1-4403H Recombinant Human LAIR1 Protein (Met1-Tyr165), C-His tagged Mammalian cells C-His Met1-Tyr165
Human LAIR1-523H Recombinant Human LAIR1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln22-His163
Human LAIR1-092H Recombinant Human LAIR1 Protein, C-His-tagged E.coli C-His
Human LAIR1-524HB Recombinant Human LAIR1 protein, His-tagged, Biotinylated HEK293 His
Human LAIR1-4404H Recombinant Human LAIR1 Protein (Gln22-His163), C-His tagged Mammalian cells C-His Gln22-His163
Human LAIR1-3325H-B Recombinant Human LAIR1 Protein Pre-coupled Magnetic Beads HEK293
Human LAIR1-0349H Active Recombinant Human LAIR1 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Gln22-His163
Mouse Lair1-6973M Recombinant Mouse Lair1 protein, Fc-tagged HEK293 Fc Gln22-Ser133
Mouse Lair1-6972M Recombinant Mouse Lair1, His tagged Human Cell His
Mouse Lair1-33M Recombinant Mouse Lair1 protein, His-tagged Insect Cell His
Mouse LAIR1-1331MCL Recombinant Mouse LAIR1 cell lysate Human Cell N/A
Mouse Lair1-1728M Recombinant Mouse Lair1 Protein, His-tagged E.coli N-His Gln22-Tyr144
Mouse LAIR1-378M Recombinant Mouse LAIR1 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 120
Rat LAIR1-3345R Recombinant Rat LAIR1 Protein Mammalian Cell His
Rat LAIR1-15R Recombinant Rat LAIR1 Protein, His-tagged E.coli His Gln22~His143
Rat LAIR1-3001R Recombinant Rat LAIR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LAIR1-3001R-B Recombinant Rat LAIR1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey LAIR1-1705R Recombinant Rhesus Monkey LAIR1 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey LAIR1-1703R Recombinant Rhesus Monkey LAIR1 Protein HEK293 N/A
Rhesus monkey LAIR1-1704R Recombinant Rhesus Monkey LAIR1 Protein, hIgG1-tagged HEK293 hIgG1
Rattus norvegicus (Rat) RFL4292RF Recombinant Full Length Rat Leukocyte-Associated Immunoglobulin-Like Receptor 1(Lair1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-263)
Rhesus Macaque LAIR1-170R Recombinant Rhesus Macaque LAIR1(Gln22-Try165) Protein, C-6*His-tagged HEK293 His
Rhesus macaque LAIR1-1706R Recombinant Rhesus macaque LAIR1 protein, Mouse IgG Fc-tagged HEK293 Mouse/IgG/Fc Gln22-Try165
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LAIR1 Related Research Area

LAIR1 involved in several pathways and played different roles in them. We selected most pathways LAIR1 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAIR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemSPSB2;SIGLEC11;AKR1C1;ASB18;KIF3B;WSB1;CTSL1;MAP3K8;DYNC1I1
Immune SystemIFIT2;SPSB1;TRIM17;SIRPB1;KIF2A;RNF19B;POLR3GLA;WWP1;KLRB1A
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellCD300C;CD300LH;CRTAM;SIGLEC5;HCST;TREML4;LILRA3;TREM1;PVRL2L

LAIR1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAIR1 itself. We selected most functions LAIR1 had, and list some proteins which have the same functions with LAIR1. You can find most of the proteins on our site.

Function Related Protein
protein bindingKIF5B;UBD;NAPA;CTC1;CTLA2B;ZNF652;LIN9;ZCCHC11;HRAS

LAIR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAIR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAIR1.

PTPN6; CSK

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How can LAIR1 impact the field of regenerative medicine? 07/12/2021

LAIR1's role in immune regulation may have implications for reducing immune rejection in regenerative medicine and tissue engineering.

Are there any ongoing clinical trials involving LAIR1 protein? 09/24/2020

Some clinical trials are exploring the therapeutic potential of targeting LAIR1 in cancer immunotherapy and autoimmune disease management.

How can LAIR1 protein impact immunotherapy approaches? 01/26/2020

LAIR1 can be targeted to enhance the effectiveness of immunotherapy, as inhibiting LAIR1 may boost the immune system's response against cancer cells.

Is LAIR1 protein involved in inflammatory conditions? 02/02/2017

Yes, LAIR1's role in immune modulation makes it relevant in inflammatory conditions. Targeting LAIR1 may be a strategy to manage inflammation.

Are there any drugs or biologics targeting LAIR1 in development? 01/16/2016

There are experimental drugs and biologics that target LAIR1 currently in preclinical and early clinical development.

Customer Reviews (3)

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Reviews
09/06/2021

    Another advantage of using LAIR1 protein in trials is its potential as a therapeutic agent.

    01/03/2020

      The manufacturer's support and expertise further enhance the utility of LAIR1 in my experimental work, ensuring reliable and high-quality results.

      01/27/2017

        This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

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