Recombinant Human LAIR1 protein, His-Avi-tagged

• Cat.No.: LAIR1-068H
• Product Overview: Human LAIR1 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Gln22-His163.

Specification

• Description: LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in 20mM PB (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 18.2 KDa. Due to glycosylation, the protein migrates to 30- 36KDa based on Bis-Tris PAGE result.
• Protein length: Gln22-His163
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: LAIR1
• Official Symbol: LAIR1
• Synonyms: CD305 antigen; CD305; CD305leukocyte-associated Ig-like receptor 1; HLAIR1; LAIR1; LAIR-1; leukocyte-associated immunoglobulin-like receptor 1
• Gene ID: 3903
• mRNA Refseq: NM_002287.3
• Protein Refseq: NP_002278.1
• MIM: 602992
• UniProt ID: Q6GTX8