Recombinant Human LAIR1 Protein, C-His-tagged

• Cat.No.: LAIR1-092H
• Product Overview: Recombinant Human LAIR1 Protein with C-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation. LAIR1 has been noted to be upregulated in renal cell carcinoma, and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue.
• Molecular Mass: ~22 kDa
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: LAIR1 leukocyte-associated immunoglobulin-like receptor 1 [ Homo sapiens (human) ]
• Official Symbol: LAIR1
• Synonyms: LAIR1; leukocyte-associated immunoglobulin-like receptor 1; leukocyte associated Ig like receptor 1; CD305; hLAIR1; leukocyte-associated Ig-like receptor 1; LAIR-1
• Gene ID: 3903
• mRNA Refseq: NM_002287
• Protein Refseq: NP_002278
• MIM: 602992
• UniProt ID: Q6GTX8