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LAMB3

  • Official Full Name

    Laminin, Beta 3

  • Overview

    The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene.
  • Synonyms

    LAMB3; laminin, beta 3; LAM5; LAMNB1; FLJ99565; BM600-125KDA; laminin subunit beta-3; nicein-125kDa; kalinin B1 chain; laminin B1k chain; OTTHUMP00000034555; OTTHUMP00000034640; laminin S B3 chain; nicein subunit beta; laminin-5 subunit beta; kalinin subunit beta;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LAMB3-225H Recombinant Human LAMB3 Protein, His/GST-tagged E.coli His/GST Gly352~Thr587
Human LAMB3-4413H Recombinant Human LAMB3 Protein (Gly352-Thr587), N-GST tagged E.coli N-GST Gly352-Thr587
Human LAMB3-2679H Recombinant Human LAMB3 protein, His-tagged E.coli His 828-1172 aa
Mouse LAMB3-8936M Recombinant Mouse LAMB3 Protein Mammalian Cell His
Mouse LAMB3-4982M Recombinant Mouse LAMB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Lamb3-226M Recombinant Mouse Lamb3 Protein, His-tagged E.coli His Glu1009~Lys1148
Mouse LAMB3-4982M-B Recombinant Mouse LAMB3 Protein Pre-coupled Magnetic Beads HEK293
Rat Lamb3-230R Recombinant Rat Lamb3 Protein, His-tagged E.coli His Cys503~Ser738
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LAMB3 Related Articles

LAMB3 involved in several pathways and played different roles in them. We selected most pathways LAMB3 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayPKN2;Ifna15;CCNE2;NOS3;KIT;IFNA1;IL7;YWHAZ;MAPK3
Focal adhesionAASS;ITGA2;COL1A1;ROCK2A;FLNC;ARHGAP35;PIK3CG;ROCK1;AKT2L
ECM-receptor interactionCOL6A1;COL2A1;TNN;GP1BB;COL6A5;SDC4;ITGAV;VTNB;ITGA2B
ToxoplasmosisITGB1;IL12B;LAMB1;TLR4;TLR2;HLA-DQA2;MAPK10;LDLR;LAMA3
AmoebiasisCOL5A1;GNA14;SERPINB1B;PTK2;GNA15;COL1A1;PIK3R2;PRKCA;RAB7A
Pathways in cancerPTCH1;LAMB2;WNT9A;CUL2;Fgf15;LAMC1;MMP1A;FASLG;BCR
Small cell lung cancerBIRC3;RARB;BIRC2;RXRA;LAMA2;TRAF3;LAMA1;TRAF2;TRAF4

LAMB3 has several biochemical functions, for example, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMB3 itself. We selected most functions LAMB3 had, and list some proteins which have the same functions with LAMB3. You can find most of the proteins on our site.

Function Related Protein
protein complex bindingFBLN1;ATP6V0D1;CDH2;UQCRC2;CAV3;MYC;TRAF2;ULK1;CD2AP

LAMB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMB3.

Ywhae

Reis, ST; Timoszczuk, LS; et al. The role of micro RNAs let7c, 100 and 218 expression and their target RAS, C-MYC, BUB1, RB, SMARCA5, LAMB3 and Ki-67 in prostate cancer. CLINICS 68:652-657(2013).
Yuen, WY; Lemmink, HH; et al. Herlitz junctional epidermolysis bullosa: diagnostic features, mutational profile, incidence and population carrier frequency in the Netherlands. BRITISH JOURNAL OF DERMATOLOGY 165:1314-1322(2011).
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