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LARS2

Official Full Name

leucyl-tRNA synthetase 2, mitochondrial
Overview

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.
Synonyms

LARS2; leucyl-tRNA synthetase 2, mitochondrial; probable leucyl-tRNA synthetase, mitochondrial; KIAA0028; leucine tRNA ligase 2; mitocondrial; LEURS; MGC26121; mitochondrial; LARS 2; Leucine translase; Leucine tRNA ligase 2 mitocondrial; Leucine tRNA ligase; Leucine--tRNA ligase; Leucyl tRNA synthetase 2; Leucyl tRNA synthetase 2 mitochondrial; Probable leucyl-tRNA synthetase; SYLM_HUMAN; OTTHUMP00000164232; OTTHUMP00000210279; OTTHUMP00000210280; leucine tRNA ligase 2, mitocondrial;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LARS2-510H	Recombinant Human LARS2, GST-tagged	E.coli	GST	554-903aa	$319 / 25ug
Human	LARS2-972HCL	Recombinant Human LARS2 cell lysate		N/A		Inquiry
Human	LARS2-2385H	Recombinant Human LARS2 Protein, His-tagged	E.coli	N-His	Leu677-Asp903	Inquiry
Mouse	LARS2-8961M	Recombinant Mouse LARS2 Protein	Mammalian Cell	His		Inquiry
Mouse	LARS2-4996M-B	Recombinant Mouse LARS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Lars2-1731M	Recombinant Mouse Lars2 Protein, His-tagged	E.coli	N-His	Gln609-Glu902	Inquiry
Mouse	LARS2-4996M	Recombinant Mouse LARS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	LARS2-6037Z	Recombinant Zebrafish LARS2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LARS2 Related Articles

LARS2 involved in several pathways and played different roles in them. We selected most pathways LARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Aminoacyl-tRNA biosynthesis	IARS2;MARS2;DARS2;TARS2;YARS;IARS;KARS;SARS;YARS2

LARS2 has several biochemical functions, for example, ATP binding, aminoacyl-tRNA editing activity, leucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LARS2 itself. We selected most functions LARS2 had, and list some proteins which have the same functions with LARS2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	NLRP10;SMYHC3;PC;CLPB;LIG3;KIAA1804;IRAK2;CKBB;PKN1B
aminoacyl-tRNA editing activity	VARS;DTD2;LARS2;IARS2;PRORSD1;VARS2;DTD1;LARS;IARS
leucine-tRNA ligase activity	LARS;LARS2

LARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LARS2.

Pierce, SB; Gersak, K; et al. Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome. AMERICAN JOURNAL OF HUMAN GENETICS 92:614-620(2013).

Li, RH; Guan, MX; et al. Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes. MOLECULAR AND CELLULAR BIOLOGY 30:2147-2154(2010).