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Official Full Name linker for activation of T cells family, member 2
Background This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental;disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all;encoding the same protein.
Synonyms LAT2; linker for activation of T cells family, member 2; WBSCR5, WBSCR15, Williams Beuren syndrome chromosome region 5; linker for activation of T-cells family member 2; HSPC046; LAB; linker for activation of B cells; linker for activation of T cells; transmembrane adaptor 2; non T cell activation linker; NTAL; WSCR5; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2; WBSCR5; WBSCR15
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LAT2-2487H Recombinant Human LAT2, His-tagged E.coli His
    Human LAT2-29925TH Recombinant Human LAT2, His-tagged E.coli His
    Human LAT2-4814HCL Recombinant Human LAT2 293 Cell Lysate HEK293 N/A
    Human LAT2-4815HCL Recombinant Human LAT2 293 Cell Lysate HEK293 N/A
    Mouse LAT2-53M Recombinant Mouse NTAL E.coli His
    Rat Lat2-1495R Recombinant Rat Lat2 protein, His & T7-tagged E.coli His/T7
    Rat LAT2-3360R Recombinant Rat LAT2 Protein Mammalian Cell His
    Rhesus Macaque LAT2-2469R Recombinant Rhesus monkey LAT2 Protein, His-tagged Mammalian Cell His
    Chicken LAT2-1742C Recombinant Chicken LAT2 Mammalian Cell His

    lat2 involved in several pathways and played different roles in them. We selected most pathways lat2 participated on our site, such as B Cell Receptor Signaling Pathway, Fc epsilon receptor (FCERI) signaling, Fc-epsilon receptor I signaling in mast cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with lat2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling Pathway CDK4; PPP3R1; PTPN6; PIK3CB; KRAS; IGHM; PPP3CB; LCP2A; LYN; NFATC1
    Fc epsilon receptor (FCERI) signaling GRAP2A; ITK; TAB1; RASGRP2; GRAP2B; LCP2A; LAT2
    Fc-epsilon receptor I signaling in mast cells LAT2; ITK; PTPN13; S1PR1; DOK1
    Immune System TRIM3; HAVCR2; KIF20A; PRLRB; KPNA5; SIGLEC6; ASB7; Mill2; RCA2.1; Siglece
    Innate Immune System ART1; CTS7; PANX1B; BAIAP2; GZMM; CR1; TXNIPB; WIPF2; BTR09; CLEC6A
    Role of LAT2/NTAL/LAB on calcium mobilization LAT2

    lat2 has several biochemical functions, for example, SH2 domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by lat2 itself. We selected most functions lat2 had, and list some proteins which have the same functions with lat2. You can find most of the proteins on our site.

    Function Related Protein
    SH2 domain binding LILRB1; LCK; CTR9; LAT2; KHDRBS2; PTK2; SYNGR3; CRK; PAG1; MS4A2
    protein binding MIS18BP1; HTR1B; IL36RN; RPH3A; TACR1; CXCR2; COPS8; RQCD1; NSL1; WDR4

    lat2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with lat2 here. Most of them are supplied by our site. Hope this information will be useful for your research of lat2.


    Imai, Y; Apakupakul, K; et al. Investigation of the Mechanism by Which Herpes Simplex Virus Type 1 LAT Sequences Modulate Preferential Establishment of Latent Infection in Mouse Trigeminal Ganglia. JOURNAL OF VIROLOGY 83:7873-7882(2009).
    Amaral, JS; Pinho, MJ; et al. Regulation of amino acid transporters in the rat remnant kidney. NEPHROLOGY DIALYSIS TRANSPLANTATION 24:2058-2067(2009).

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