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LATS2

Official Full Name

large tumor suppressor kinase 2
Overview

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Synonyms

LATS2; large tumor suppressor kinase 2; KPM; serine/threonine-protein kinase LATS2; warts-like kinase; serine/threonine kinase KPM; large tumor suppressor homolog 2; serine/threonine-protein kinase kpm; LATS, large tumor suppressor, homolog 2; kinase phosphorylated during mitosis protein; LATS (large tumor suppressor, Drosophila) homolog 2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Sf9 Insect Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LATS2-381H	Recombinant Human LATS2, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	LATS2-28502TH	Recombinant Human LATS2		N/A		Inquiry
Human	LATS2-1541H	Recombinant Human LATS2, Unactive, GST-tagged	Sf9 Insect Cell	GST	480-1088 aa	Inquiry
Human	LATS2-4813HCL	Recombinant Human LATS2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	LATS2-301645H	Recombinant Human LATS2 protein, GST-tagged	E.coli	GST	Met140-Pro424	Inquiry
Zebrafish	LATS2-6821Z	Recombinant Zebrafish LATS2	Mammalian Cell	His		Inquiry
Zebrafish	LATS2-6686Z	Recombinant Zebrafish LATS2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LATS2 Related Articles

LATS2 involved in several pathways and played different roles in them. We selected most pathways LATS2 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LATS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hippo signaling pathway	SMAD1;SNAI2;WNT2B;TGFBR1;WTIP;WWC1;AXIN2;APC;DLG1

LATS2 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LATS2 itself. We selected most functions LATS2 had, and list some proteins which have the same functions with LATS2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TBK1;FGR;NTRK2B;ABCG4B;RUNX2B;PIK3C2B;NETO2;PDPK1B;UBE2G2
metal ion binding	GPR39;PPTC7A;IDI2;KLF11A;ATP1A1A.1;ITGAV;Ar;DNMT3L;ADCY1
protein binding	STK25;ID1;AMELX;PLK1S1;CCHCR1;STK3;SOCS6;NVL;HIST1H4H
protein serine/threonine kinase activity	SGK2B;GM4922;GM711;EIF2AK2;PLK2B;CSNK1G2;TSSK4;TGFBR1;SLC14A2

LATS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LATS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LATS2.

MOB1A; MOB1B; AJUBA; VPRBP; SNAI1; UBI1; LATS1; LMNA

Meistermann, H; Gao, JJ; et al. A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation. MOLECULAR & CELLULAR PROTEOMICS 13:3040-3048(2014).

Chan, SW; Lim, CJ; et al. Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:37296-37307(2013).