LGR6
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Official Full Name
leucine-rich repeat containing G protein-coupled receptor 6
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Overview
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. -
Synonyms
LGR6; leucine-rich repeat containing G protein-coupled receptor 6; leucine rich repeat containing G protein coupled receptor 6; leucine-rich repeat-containing G-protein coupled receptor 6; FLJ14471; gonadotropin receptor; leucine-rich repeat-containing G;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Mouse
- CHO
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- C
- Fc
- mFc
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- LGR6 Related Articles
- LGR6 Related Signal Pathway
LGR6 involved in several pathways and played different roles in them. We selected most pathways LGR6 participated on our site, such as GPCRs, Other, Regulation of FZD by ubiquitination, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGR6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Other | ADORA3;LGR6;GPR77;EMR2;CELSR1;GPR162;VMN1R48;GPR88;OR3A4P |
| Regulation of FZD by ubiquitination | RSPO3;LGR5;LGR4;RNF43;FMNL3;ZNRF3;LGR6;RSPO2;RSPO1 |
| Signal Transduction | OPHN1;ARHGAP23;GAS8;SAGB;BBS13;TNKS;MYO7A;ARHGAP17;FGD2 |
| Signaling by Wnt | CDC73;ROR2;PRICKLE1B;WIF1;LGR5;LGR6;TMED5;PYGO2;DACT1 |
| TCF dependent signaling in response to WNT | KLHL12;PYGO2;USP34;TNKS2;SOX9B;C;SRY;CCDC88C;BCL9 |
LGR6 has several biochemical functions, for example, NOT G-protein coupled receptor activity, protein binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LGR6 itself. We selected most functions LGR6 had, and list some proteins which have the same functions with LGR6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT G-protein coupled receptor activity | SFRP1A;SFRP4;SZL;FRZB;SFRP2;LGR6;LGR4;LGR5;SFRP1B |
| protein binding | PNKP;GEMIN6;HSPA4;GPS2;BCL11B;GHITM;BLCAP;RRAS;SEPHS1 |
| transmembrane signaling receptor activity | VIPR1B;SLAMF1;GPR98;TLR4;EVI2A;PTH1RB;OR115-6;FZD1;OR4F29 |
LGR6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGR6 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGR6.
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