LIAS
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Official Full Name
lipoic acid synthetase
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Overview
The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. -
Synonyms
LIAS; lipoic acid synthetase; lipoyl synthase, mitochondrial; LAS; lip-syn; lipoate synthase; LS; LIP1; PDHLD; HUSSY-01; MGC23245;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E. coli or Yeast
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- LIAS Related Articles
LIAS involved in several pathways and played different roles in them. We selected most pathways LIAS participated on our site, such as Lipoic acid metabolism, Metabolic pathways, lipoate biosynthesis and incorporation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lipoic acid metabolism | LIAS;LIPT1;LIPT2 |
| Metabolic pathways | LIPC;ST6GALNAC1;PLCB4;ALDH3A1;LDHB;ACADVL;GALNTL4;POLD2;QDPRB2 |
| lipoate biosynthesis and incorporation |
LIAS has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, lipoate synthase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIAS itself. We selected most functions LIAS had, and list some proteins which have the same functions with LIAS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4 iron, 4 sulfur cluster binding | MOCS1;IREB2;ACO2;TYW1B;RSAD2;RTEL1;NDUFS8;NDUFV1;ISCU |
| lipoate synthase activity | |
| metal ion binding | ZNF764;ETFDH;DPH3P1;PPP1CA;NFS1;CSGALNACT2;ARSH;TIMP3;KLK1B3 |
LIAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIAS here. Most of them are supplied by our site. Hope this information will be useful for your research of LIAS.
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