lig4 Protein, ligase IV, DNA, ATP-dependent


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Official Full Name ligase IV, DNA, ATP-dependent
Background The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Synonyms LIG4; ligase IV, DNA, ATP-dependent; DNA ligase 4; sealase; DNA joinase; DNA ligase IV; DNA repair enzyme; polynucleotide ligase; polydeoxyribonucleotide synthase [ATP] 4;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LIG4-4745HCL Recombinant Human LIG4 293 Cell Lysate HEK293 N/A
    Human LIG4-4746HCL Recombinant Human LIG4 293 Cell Lysate HEK293 N/A
    Human LIG4-508H Recombinant Human LIG4 protein, GST-tagged Wheat Germ GST
    Mouse LIG4-9098M Recombinant Mouse LIG4 Protein Mammalian Cell His
    Chicken LIG4-2513C Recombinant Chicken LIG4 Mammalian Cell His
    Zebrafish LIG4-5960Z Recombinant Zebrafish LIG4 Mammalian Cell His

    lig4 involved in several pathways and played different roles in them. We selected most pathways lig4 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with lig4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-homologous end-joining XRCC6; NHEJ1; PRKDC; LIG4; XRCC5; POLM; MRE11A; DCLRE1C; POLL; DNTT

    lig4 has several biochemical functions, for example, ATP binding, DNA binding, DNA ligase (ATP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by lig4 itself. We selected most functions lig4 had, and list some proteins which have the same functions with lig4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ATP2B3A; ABCD3; STK3; TRPV4; UBE2Q1; Acsm2a; WEE2; ATP6V1B2; PEBP1; ACTA2
    DNA ligase (ATP) activity LIG1; LIG3; LIG4
    DNA ligase activity LIG4; LIG1; LIG3
    ligase activity PDZRN3; RNF126; NEURL3; MARCH1; PIAS3; GATB; BIRC7; PCXA; TRIM69; RNF149
    metal ion binding ZNF165; CYP46A1.3; ZNF217; KLF18; LHX8A; RRM2B; SNRNP48; CLCA2; OSGEP; IHHB
    protein C-terminus binding HRAS; TRP53; NEIL1; SLC9A3R2; KCNK3; AGO2; PEX10; DAB2; MAP3K7; AXIN1
    protein binding CDC16; CTSC; DDAH2; UFC1; FOXP2; CAPN3; H3F3C; TOB1A; CRTC1; IL13RA1

    lig4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with lig4 here. Most of them are supplied by our site. Hope this information will be useful for your research of lig4.


    Cordoba-Canero, D; Roldan-Arjona, T; et al. Arabidopsis ARP endonuclease functions in a branched base excision DNA repair pathway completed by LIG1. PLANT JOURNAL 68:693-702(2011).
    Paddock, MN; Bauman, AT; et al. Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair. DNA REPAIR 10:338-343(2011).

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