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LIMS1

Official Full Name

LIM and senescent cell antigen-like domains 1
Overview

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Synonyms

LIMS1; LIM and senescent cell antigen-like domains 1; PINCH; PINCH1; PINCH-1; LIM and senescent cell antigen-like-containing domain protein 1; renal carcinoma antigen NY-REN-48; particularly interesting new Cys-His protein 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LIMS1-29952TH	Recombinant Human LIMS1	Wheat Germ	Non	325 amino acids	Inquiry
Human	LIMS1-4736HCL	Recombinant Human LIMS1 293 Cell Lysate	HEK293	Non		Inquiry
Human	LIMS1-284HF	Recombinant Full Length Human LIMS1 Protein	In Vitro Cell Free System		325 amino acids	Inquiry
Human	LIMS1-1873H	Recombinant Human LIMS1 protein, GST-tagged	E.coli	GST	1-325 aa	$319 / 25μg
Human	LIMS1-1507H	Recombinant Human LIMS1 protein, His & T7-tagged	E.coli	His&T7	Ala68~Cys303	Inquiry
Human	LIMS1-4448H	Recombinant Human LIMS1 Protein (Ala68-Cys303), N-His tagged	E.coli	His	Ala68-Cys303	Inquiry
Mouse	LIMS1-9110M	Recombinant Mouse LIMS1 Protein	Mammalian Cell	His		Inquiry
Mouse	LIMS1-5087M-B	Recombinant Mouse LIMS1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	LIMS1-2784M	Recombinant Mouse LIMS1 Protein (2-325 aa), His-tagged	Insect Cell	His	2-325 aa	Inquiry
Mouse	LIMS1-2655M	Recombinant Mouse LIMS1 Protein (2-325 aa)	E.coli	Non	2-325 aa	Inquiry
Mouse	LIMS1-5087M	Recombinant Mouse LIMS1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Zebrafish	LIMS1-2996Z	Recombinant Zebrafish LIMS1	Mammalian Cell	His		Inquiry
Chicken	LIMS1-1161C	Recombinant Chicken LIMS1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

LIMS1 involved in several pathways and played different roles in them. We selected most pathways LIMS1 participated on our site, such as Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell junction organization	PLECA;COL17A1A;CDH5;CADM2A;CDH10;CTNND1;CDH2;CDH9;CDH11
Cell-Cell communication	RSU1;DSCAML1;CDH12A;CDH5;PVRL1A;CDH18;CADM2;CLDN23;COL17A1A
Cell-extracellular matrix interactions	FBLIM1;TESK1;ITGB1B.1;LIMS1;PARVB;FERMT2;RSU1
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	LIMS1;PARVB;RSU1;TESK1

LIMS1 has several biochemical functions, for example, protein binding, protein kinase binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMS1 itself. We selected most functions LIMS1 had, and list some proteins which have the same functions with LIMS1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	NOL11;ARR3;PPP1R2P3;PARD3;GAST;IL1R1;TRAPPC6B;CCER1;PPP1R16A
protein kinase binding	TTN;FGR;EMP2;CALM;CD226;CCNE1;ILK;PDCD10;BAD
zinc ion binding	GATA2A;ZDHHC9;RNF123;LPP;TRIM12A;ZZEF1;KLF7;RNF181;ZDHHC11

LIMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMS1.

ILK; RSU1; NCK2; Ilk; Hoxa1

Research Area

Focal Adhesion Adaptor and Scaffold Proteins

EMT Induction

Li, SH; Bordoy, R; et al. PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. JOURNAL OF CELL SCIENCE 118:2913-2921(2005).