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LMTK2

Official Full Name

lemur tyrosine kinase 2
Overview

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
Synonyms

LMTK2; lemur tyrosine kinase 2; serine/threonine-protein kinase LMTK2; AATYK2; BREK; cprk; KIAA1079; KPI 2; KPI2; LMR2; hBREK; brain-enriched kinase; CDK5/p35-regulated kinase; kinase phosphatase inhibitor 2; kinase/phosphatase/inhibitor 2; serine/threoni;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	LMTK2-9162M	Recombinant Mouse LMTK2 Protein	Mammalian Cell	His	Inquiry
Mouse	LMTK2-5121M-B	Recombinant Mouse LMTK2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	LMTK2-5121M	Recombinant Mouse LMTK2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
LMTK2 Related Articles
LMTK2 Related Research Area

LMTK2 involved in several pathways and played different roles in them. We selected most pathways LMTK2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LMTK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

LMTK2 has several biochemical functions, for example, ATP binding, kinase activity, myosin VI binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMTK2 itself. We selected most functions LMTK2 had, and list some proteins which have the same functions with LMTK2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MYH9A;KIT;ACSM2;KIF13B;PRKDC;PFKFB2;STK24A;FES;NIM1K
kinase activity	EPHB4A;MKNK2A;AK5L;CDK5R1B;PKMYT1;FYNA;PRKCBA;BAIAP2L1A;ERBB3B
myosin VI binding
nucleotide binding	GLULA;SMG1;DAZ4;DND1;FYNB;ATP1A1A.3;PDPK1B;RBM14B;CMPK
protein kinase activity	ROCK2A;PKZ;PKN3;SLKA;RBM4.3;PPP1R9B;PRKCBB;MAP3K3;PRKCA
protein phosphatase inhibitor activity	ENSAA;PPME1;PPP1R14C;PPP1R36;GLC8;PPP1R10;PPP1R27;PHACTR1;DYSFIP1
protein serine/threonine kinase activity	MKNK2;PKN1;CHEK1;PAK2A;ROCK2A;LMTK2;MAST4;CDK11A;ACVR1B
transferase activity	ZDHHC24;ELOVL1A;UCK2A;C1GALT1A;SAT1A.2;Aatk;BMPR2B;PTK2AA;SULT3ST2

LMTK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMTK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMTK2.

PPP1R2

Xu, YC; Zhang, H; et al. The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin beta(1). SCIENCE SIGNALING 7:-(2014).

Luz, S; Cihil, KM; et al. LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:15080-15093(2014).

Apoptosis Intracellular Kinases