LRAT
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Official Full Name
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
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Overview
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. -
Synonyms
LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase); lecithin retinol acyltransferase; LCA14; MGC33103;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Rat
- Rhesus Macaque
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Tag
- Free
- Involved Pathway
- Protein Function
- Interacting Protein
- LRAT Related Articles
LRAT involved in several pathways and played different roles in them. We selected most pathways LRAT participated on our site, such as Retinol metabolism, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Retinol metabolism | CYP2A4;RDH8;RDH10B;DHRS9;SDR16C5B;LRAT;HSD17B6;UGT1A3;UGT1A9 |
Vitamin digestion and absorption | ABCC1;SCARB1;APOB;SLC5A6;BTD;GIF;PNLIP;CUBN;APOA1 |
LRAT has several biochemical functions, for example, phosphatidylcholine-retinol O-acyltransferase activity, retinoic acid binding, retinol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRAT itself. We selected most functions LRAT had, and list some proteins which have the same functions with LRAT. You can find most of the proteins on our site.
Function | Related Protein |
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phosphatidylcholine-retinol O-acyltransferase activity | |
retinoic acid binding | LCN12;SERPINA5;UGT1A9;UGT1A1;CYP26A1;CRABP2;CRABP1B;PTGDSB;UGT1A3 |
retinol binding | CRABP2;RBP7;RBP1;C8G;ADH4;RBP4;RLBP1;RBP5;LRAT |
transferase activity, transferring acyl groups | ZDHHC1;GM4952;ZDHHC8B;CHATB;ZDHHC15B;ZDHHC13;LRAT;ACAA1A;GGACT.3 |
LRAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LRAT.
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