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LRAT

  • Official Full Name

    lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)

  • Overview

    The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.
  • Synonyms

    LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase); lecithin retinol acyltransferase; LCA14; MGC33103;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LRAT-4660HCL Recombinant Human LRAT 293 Cell Lysate HEK293 N/A
Human LRAT-4711H Recombinant Human LRAT Protein, GST-tagged Wheat Germ GST
Human LRAT-6002HF Recombinant Full Length Human LRAT Protein, GST-tagged In Vitro Cell Free System GST 230 amino acids
Human LRAT-4363H Recombinant Human LRAT Full Length Transmembrane protein In vitro E. coli expression system N/A 1-230aa
Rat LRAT-3448R Recombinant Rat LRAT Protein Mammalian Cell His
Rat LRAT-3104R Recombinant Rat LRAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LRAT-3104R-B Recombinant Rat LRAT Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL743HF Recombinant Full Length Human Lecithin Retinol Acyltransferase(Lrat) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-230aa)
Rhesus Macaque LRAT-2546R Recombinant Rhesus monkey LRAT Protein, His-tagged Mammalian Cell His
Rhesus Macaque LRAT-2366R Recombinant Rhesus Macaque LRAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LRAT-2366R-B Recombinant Rhesus Macaque LRAT Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LRAT Related Articles

LRAT involved in several pathways and played different roles in them. We selected most pathways LRAT participated on our site, such as Retinol metabolism, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Retinol metabolismCYP2A4;RDH8;RDH10B;DHRS9;SDR16C5B;LRAT;HSD17B6;UGT1A3;UGT1A9
Vitamin digestion and absorptionABCC1;SCARB1;APOB;SLC5A6;BTD;GIF;PNLIP;CUBN;APOA1

LRAT has several biochemical functions, for example, phosphatidylcholine-retinol O-acyltransferase activity, retinoic acid binding, retinol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRAT itself. We selected most functions LRAT had, and list some proteins which have the same functions with LRAT. You can find most of the proteins on our site.

Function Related Protein
phosphatidylcholine-retinol O-acyltransferase activity
retinoic acid bindingLCN12;SERPINA5;UGT1A9;UGT1A1;CYP26A1;CRABP2;CRABP1B;PTGDSB;UGT1A3
retinol bindingCRABP2;RBP7;RBP1;C8G;ADH4;RBP4;RLBP1;RBP5;LRAT
transferase activity, transferring acyl groupsZDHHC1;GM4952;ZDHHC8B;CHATB;ZDHHC15B;ZDHHC13;LRAT;ACAA1A;GGACT.3

LRAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LRAT.

Brown, GT; Cash, BG; et al. The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer. PLOS ONE 9:-(2014).
Nagatsuma, K; Hano, H; et al. Hepatic stellate cells that coexpress LRAT and CRBP-1 partially contribute to portal fibrogenesis in patients with human viral hepatitis. LIVER INTERNATIONAL 34:243-252(2014).
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