LTBR

  • Official Full Name

    lymphotoxin beta receptor (TNFR superfamily, member 3)

  • Overview

    The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
  • Synonyms

    LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; CD 18; CD18; CD18 antigen; LT beta R; LTBETAR; Lymphotoxin B receptor; Lymphotoxin beta receptor; TNFR superfamily member 3; TNFR2RP; TNFRII; TNFRRP; TNFRSF 3; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2 related protein; Tumor necrosis factor receptor superfamily member 3 precursor; TNF-RIII; TNFR-III; OTTHUMP00000238625; OTTHUMP00000238626; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor receptor type II; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III;

  • Recombinant Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 Cells
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • C
  • Fc
  • hFc
  • Fc Chimera
  • His(C
  • ter)
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LTBR-745H Active Recombinant Human LTBR, Fc Chimera Mammalian cells Fc Chimera
Human LTBR-633H Active Recombinant Human LTBR, MIgG2a Fc-tagged CHO Fc
Human LTBR-635H Active Recombinant Human LTBR protein, Fc-tagged CHO Fc
Human LTBR-746H Active Recombinant Human LTBR, Fc Chimera CHO Fc Chimera
Human LTBR-634H Active Recombinant Human LTBR, HIgG1 Fc-tagged CHO Fc
Human LTBR-636H Active Recombinant Human LTBR, Fc-tagged, Biotinylated Human Cell Fc
Human LTBR-961HB Active Recombinant Human LTBR protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human LTBR-960H Recombinant Human LTBR Protein, His-tagged HEK293 His
Human LTBR-2683H Recombinant Human LTBR protein, His-tagged E.coli His
Human LTBR-398H Active Recombinant Human LTBR, Fc-tagged CHO Fc
Human LTBR-2090H Recombinant Human LTBR, FC Chimera HEK293 Fc
Human LTBR-1665H Recombinant Human LTBR, His-tagged Mammalian cells His
Human LTBR-674H Recombinant Human lymphotoxin beta receptor (TNFR superfamily, member 3), His-tagged E.coli His
Human LTBR-4589H Recombinant Human LTBR Protein, GST-tagged Wheat Germ GST
Human LTBR-1752H Recombinant Human LTBR Protein, His&GST-tagged E.coli N-His&GST
Human DMABT-H19157 Mouse Anti-LTBR Monoclonal Antibody Mouse N/A
Human LTBR-190H Recombinant Human LTBR protein, Fc-tagged HEK293 Cells Fc
Human LTBR-5243H Recombinant Human LTBR protein, His-tagged E.coli His
Human LTBR-235H Recombinant Human LTBR Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
Human LTBR-200H-B Recombinant Human LTBR Protein Pre-coupled Magnetic Beads HEK293
Human LTBR-200H Recombinant Human LTBR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LTBR-1840H Recombinant Human LTBR protein, His-tagged, PE Labeled HEK293 His
Human LTBR-369H Recombinant Human LTBR Protein, Fc-tagged HEK293 Fc
Human LTBR-399H Recombinant Human LTBR protein, Fc-tagged HEK293 human/IgG1/Fc
Human LTBR-0360H Active Recombinant Human LTBR protein, Fc-tagged HEK293 Fc
Human LTBR-4467H Recombinant Human LTBR Protein (Gln31-Met227), N-His tagged E.coli N-His
Human LTBR-4466H Recombinant Human LTBR Protein (Gln31-Met227), C-Fc tagged Mammalian cells C-Fc
Human LTBR-8493H Recombinant Human LTBR Protein, Fc-tagged CHO Fc
Human LTBR-6208HF Recombinant Full Length Human LTBR Protein, GST-tagged In Vitro Cell Free System GST
Mouse LTBR-4557M Active Recombinant Mouse LTBR, MIgG2a Fc-tagged CHO Fc
Mouse LTBR-4556M Active Recombinant Mouse LTBR, MIgG2a Fc-tagged, mutant CHO Fc
Mouse Ltbr-1219M Active Recombinant Mouse Ltbr Protein, Fc-tagged HEK293 Fc
Mouse Ltbr-2684M Recombinant Mouse Ltbr protein, His & GST-tagged E.coli His/GST
Mouse Ltbr-1751M Recombinant Mouse Ltbr Protein, His-tagged E.coli N-His
Rat Ltbr-381R Recombinant Rat Ltbr protein, His-tagged HEK293 His
Rat LTBR-380R Recombinant Rat Ltbr, Fc tagged Human Cell His
Rat LTBR-1052RCL Recombinant Rat LTBR cell lysate Human Cell N/A
Rat LTBR-1288R Recombinant Rat LTBR protein(Met1-Ala218), hFc-tagged HEK293 C-hFc
Cynomolgus LTBR-8827C Recombinant Cynomolgus LTBR protein, hFc-tagged HEK293 hFc
Cynomolgus Monkey LTBR-1229CCL Recombinant Cynomolgus LTBR cell lysate Human Cell N/A
Homo sapiens (Human) RFL35243HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 3(Ltbr) Protein, His-Tagged E.coli expression system His
Rhesus Macaque LTBR-2591R Recombinant Rhesus monkey LTBR Protein, His-tagged Mammalian Cell His
Rhesus Macaque LTBR-2411R-B Recombinant Rhesus Macaque LTBR Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque LTBR-2411R Recombinant Rhesus Macaque LTBR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LTBR Related Gene Family
  • LTBR Related Research Area
  • LTBR Related Signal Pathway

LTBR involved in several pathways and played different roles in them. We selected most pathways LTBR participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTBR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionHGF;PF4;Ccl12;IL10RA;IL6R;BMPR1AB;Ifna15;ACVR1BA;CCL19
NF-kappa B signaling pathwayTICAM2;LTBR;GM10591;BTK;CXCL2;TRAF2;TAB2;IKBKB;TRAF5
HIF- signaling pathwayENO1;PGK1;INSR;PLCG1;IFNG;TCEB2;RBX1;CAMK2B;IL6
Intestinal iIL-15RA;CD28;IL4;MHC2A;CCL27B;AICDA;HLA-DQA2;HLA-DMB;HLA-DPB1
ne network for IgA productionHLA-DMB;CD86;CCR9A;MHC2DAB;CCL27B;MHC2A;Il2;IL6;CXCL12A
HTLV-I infectionHLA-DOB;WNT8A;EGR1;TBPL1;LTBR;POLE2;RAN;XIAP;Fzd4
Viral carcinogenesisYWHAZ;HIST1H2BM;PIK3R1;HIST2H2BE;GTF2H2C_2;HLA-E;HDAC9;HIST1H4C;ATP6V0D1

LTBR has several biochemical functions, for example, identical protein binding, protein binding, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LTBR itself. We selected most functions LTBR had, and list some proteins which have the same functions with LTBR. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingNONO;PPP1R13L;SOD1;PCBD1;HOOK3;ALK;SMG9;SDCBP;ALDOB
protein bindingMYLK;NGFR;OSTC;TMEM147;TNFAIP3;MBL2;NSL1;RFC4;CDK8
tumor necrosis factor-activated receptor activityCD27;LTBR;TNFRSF11A;TNFRSF18;TNFRSF1A;TNFRSF10C;NGFR;TNFRSF9;NRADD
ubiquitin protein ligase bindingHSPA8;UBXN6;WASH1;DNAJA1;GLMN;UBE2G1A;HSPA1L;GABARAP;CCT2

LTBR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTBR here. Most of them are supplied by our site. Hope this information will be useful for your research of LTBR.

p29846-pro_0000037666; ZMYND11; DEAF1; TRAF2; TRAF3; BALF4 (provisional); HES1; q00653-pro_000003032; Bmpr1a; NFKB2

TNF
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What therapeutic strategies can be employed to target LTBR? 12/18/2022

Therapeutic strategies targeting LTBR include inhibition of its signaling pathways, modulation of immune response, and anti-cancer approaches. Inhibitors of the NF-κB pathway, such as small molecule inhibitors or neutralizing antibodies, can be used to block LTBR-mediated signaling and reduce inflammation or tumor growth.

What is the current research focus regarding the role of LTBR in disease mechanisms? 11/12/2021

Current research on LTBR aims to further elucidate its role in disease mechanisms, particularly in autoimmune disorders, chronic inflammation, and cancer. Studies are investigating the downstream effects of LTBR activation, its involvement in immune cell function, and the identification of potential therapeutic targets within the LTBR signaling pathway.

How is the expression of LTBR regulated at the transcriptional level? 06/26/2021

The expression of LTBR is regulated by transcription factors and signaling pathways. For example, NF-κB and AP-1 transcription factors can bind to the promoter region of LTBR gene and enhance its expression. Additionally, cytokines and growth factors can also influence LTBR expression through downstream signaling cascades.

How does the LTBR signaling pathway interact with other signaling pathways? 07/18/2020

The LTBR signaling pathway interacts with various other signaling pathways, including those activated by TNFR1, TNFR2, and CD40. These interactions can lead to crosstalk and amplification of signaling, resulting in enhanced cellular responses. Understanding these interactions is crucial for elucidating the complex network of signaling events involved in disease pathogenesis.

What is the biological function of LTBR and its involvement in cellular processes? 04/13/2018

LTBR, a membrane protein belonging to the tumor necrosis factor receptor superfamily, regulates various cellular processes such as inflammation, immune response, and lymphoid organ development. It activates signaling pathways including the NF-κB pathway and non-canonical NF-κB pathway.

Are there any genetic variants associated with LTBR expression and disease susceptibility? 01/06/2017

Yes, certain genetic variants have been identified that are associated with altered LTBR expression and disease susceptibility. These variants can affect the binding of transcription factors or alter the stability of LTBR mRNA, leading to dysregulation of LTBR expression and increased risk of certain diseases.

What are the potential future directions in LTBR research? 11/21/2016

Future research directions in LTBR include exploring the molecular mechanisms underlying LTBR-mediated signaling, investigating the impact of LTBR genetic variants on disease susceptibility, and developing novel therapeutic strategies targeting LTBR. Additionally, studying the interplay between LTBR and other signaling pathways may uncover new insights into disease pathogenesis and identify new therapeutic avenues.

Customer Reviews (3)

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Reviews
04/20/2020

    Unrivaled in efficiency, this innovative elixir leaves me awestruck.

    12/31/2019

      By using this reagent, I can better investigate protein interactions.

      02/09/2018

        The interpretation of the results provided by this reagent is clear, allowing me to better understand the experimental outcomes.

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