MAK
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Official Full Name
male germ cell-associated kinase
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Overview
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MAK; male germ cell-associated kinase; serine/threonine-protein kinase MAK; dJ417M14.2; serine/threonine protein kinase MAK; male germ cell-associated kinase retinal-enriched isoform; RP62;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- MAK Related Articles
MAK involved in several pathways and played different roles in them. We selected most pathways MAK participated on our site, such as Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Coregulation of Androgen receptor activity | PAWR;CMTM2A;ZMIZ1;PATZ1;SNURF;TMF1;KDM3A;TCF4;TGFB1I1 |
MAK has several biochemical functions, for example, ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAK itself. We selected most functions MAK had, and list some proteins which have the same functions with MAK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | STK38L;DYRK1B;TOR2A;NADK;PAPSS2B;PI4K2B;IKBKAP;SRPK2;PFKP |
| cyclin-dependent protein serine/threonine kinase activity | CDK14;CDKL5;STK30;CDK1;CDK5;MAK;CDK20;CDK13;CDK11B |
| protein binding | LGALS14;GINS2;ATG101;ASS1;HIST2H3C;C3orf52;SLX4;MTA3;ADI1 |
| protein kinase activity | EPHB3A;JAK2B;RPS6KA3A;IGF1RA;RAF1;JAK2;PKN1B;KITA;MAPKAPK2A |
| transcription coactivator activity | TAF1;TAF5L;MKL1;PIAS2;NFATC4;ING4;VGLL2;TRIM24;RAN |
MAK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAK here. Most of them are supplied by our site. Hope this information will be useful for your research of MAK.
FZR1; AR; CDC37; CDK20; NDUFB7; PPP2CB; SND1; SLAMF7; SERINC1; ANAPC11
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