MAP1B
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Official Full Name
microtubule-associated protein 1B -
Overview
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are;thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene;is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain;and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important;role in development and function of the nervous system. -
Synonyms
MAP1B;microtubule-associated protein 1B;MAP5;MAP-1B;FUTSCH;FLJ38954;DKFZp686E1099;DKFZp686F1345
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- T7
- Avi
- Fc
- GST
Involved Pathway
MAP1B involved in several pathways and played different roles in them. We selected most pathways MAP1B participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development,Reelin signaling pathway,Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lissencephaly gene (LIS1) in neuronal migration and development | NUDC,KATNA1,LRPAP1,DCX,VLDLR,DAB1,NDEL1,DYNLT1 |
| Regulation of Microtubule Cytoskeleton | CFL2,MARK1,TESK2,TPPP,DPYSL2,MARK2 |
| Reelin signaling pathway | VLDLR,DAB1,LRPAP1 |
| Wnt Signaling Pathway NetPath | BRD7,SOX1,MTAP1B,SALL1,NR5A1,HIPK2,ANKRD6,MARK2,PAX2,ROR2 |
Protein Function
MAP1B has several biochemical functions, for example, microtubule binding,protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP1B itself. We selected most functions MAP1B had, and list some proteins which have the same functions with MAP1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | KRT12,KRT33B,MATR3,KRT95,EPB41L3B,IFFO2,OC90,CKI,CLDN9,INAA |
| protein binding | EXOSC5,TRIM74,CTIF,KIF3B,NR3C1,RAB34,RRM1,CCDC110,MT1A,COPS7A |
| microtubule binding | BCL2L11,KIF2A,WDR43,CHP1,RCC2,TERF1,MAPRE2,KIFC3,KIF3A,HAUS8 |
Interacting Protein
MAP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP1B.
STK4;MAP1LC3B;TP53;RASSF5;GAN
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References
- El Fatimy, R; Tremblay, S; et al. Fragile Mental Retardation Protein Interacts with the RNA-Binding Protein Caprin1 in Neuronal RiboNucleoProtein Complexes. PLOS ONE 7:-(2012).
- Rudrabhatla, P; Jaffe, H; et al. Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs. FASEB JOURNAL 25:3896-3905(2011).
