Map2
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Official Full Name
microtubule-associated protein 2
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Overview
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010] -
Synonyms
MAP2; microtubule-associated protein 2; MAP2A; MAP2B; MAP2C; MAP-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- Myc
- DDK
- Flag
- His (Fc)
- Avi
- His|GST
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Map2 Related Articles
- Map2 Related Research Area
Map2 involved in several pathways and played different roles in them. We selected most pathways Map2 participated on our site, such as LKB1 signaling events, MAPK Cascade, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| LKB1 signaling events | CDC37;MAP2;CTSD;MARK2;SIK3;STK11IP;MARK4 |
| MAPK Cascade | MBP;MAP2;MAP3K2;MBPB |
| SIDS Susceptibility Pathways | PLP1;ASCL1;EN1;SST;MECP2;PHOX2B;TPH2;CTCF;MBD1 |
Map2 has several biochemical functions, for example, calmodulin binding, dystroglycan binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2 itself. We selected most functions Map2 had, and list some proteins which have the same functions with Map2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | CAMK1G;PDE1C;GM101;MAP2;PDE1B;CALD1;RRAD;SNTB1;KCNH5 |
| dystroglycan binding | AGR3;VCL;MAP2;GYLTL1B;DMD;AGRN;CLASP1;DAG1;AGR2 |
| microtubule binding | FNTA;RAE1;WDR81;KATNAL2;WHAMM;FMR1;MID2;RCC2;MAPRE3 |
| protein binding | ANTXR1;PPIE;FGF1;TWIST1;DDX41;C17orf81;SNX19;MYO10;GSTO1 |
| structural molecule activity | LMNA;NGS;CLDN11A;TUBB;SEPT4;CLDN1;KRT3;CLDN9;PRPH |
Map2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2.
GRB2; CalpB; JUNB; MDM2; CBFB; SCHIP1; 3',5'-cyclic amp; 8-aha-camp; 8-aha-omethyladenosine; PTBP3; p27958-pro_0000037566
- Q&As
- Reviews
Q&As (6)
Ask a questionFuture research on MAP2 may involve its mechanism of action in neurological diseases, its interaction with other proteins, etc.
MAP2 may be associated with certain neurological diseases, such as Alzheimer's disease and Parkinson's disease. However, there is still insufficient research on this aspect.
There are still many controversial and unresolved issues in the current research on MAP2, such as its mechanism of action in neurological diseases.
The effects of MAP2 on neuronal structure and function, as well as its role in neurological diseases, can be studied through experimental methods such as cell culture and animal models.
MAP2 is unevenly distributed in neurons and is mainly concentrated in axons and dendrites, with a higher density in dendrites.
The MAP2 may affect the process of learning Xi and memory by affecting the structure and function of neurons. However, there is insufficient research on this aspect.
Customer Reviews (3)
Write a reviewI've been using them for several years now and they've been stable and I trust this product a lot.
It is very suitable for biological activity experiments, and the activity is good.
It can meet the needs of daily experiments and has good expression effect.
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