Map2

  • Official Full Name

    microtubule-associated protein 2

  • Overview

    This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
  • Synonyms

    MAP2; microtubule-associated protein 2; MAP2A; MAP2B; MAP2C; MAP-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • Flag
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2-28460TH Recombinant Human MAP2 Wheat Germ N/A 471 amino acids
Human MAP2-284H Recombinant Human MAP2 Mammalian Cell His
Human MAP2-6820H Recombinant Human MAP2 protein, His-tagged E.coli His Leu727~Asp985
Human MAP2-4512HCL Recombinant Human MAP2 293 Cell Lysate HEK293 N/A
Human MAP2-047H Recombinant Human MAP2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human MAP2-1351H-B Recombinant Human MAP2 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2-293HF Recombinant Full Length Human MAP2 Protein In Vitro Cell Free System 471 amino acids
Human MAP2-3919H Recombinant Human MAP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP2-214HFL Recombinant Full Length Human MAP2 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2-1351H Recombinant Human MAP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2-2633H Recombinant Human MAP2 protein(401-500 aa), C-His-tagged E.coli C-His 401-500 aa
Human MAP2-4493H Recombinant Human MAP2 Protein (Gly1689-Lys1824), N-His tagged E.coli N-His Gly1689-Lys1824
Mouse Map2-6821M Recombinant Mouse Map2 protein, His & GST-tagged E.coli His/GST Thr1457~Ser1728 (Accession # P20357)
Mouse Map2-3919M Recombinant Mouse Map2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Map2-3201M Recombinant Mouse Map2 protein, His-SUMO-tagged E.coli His-SUMO 213-559aa
Mouse Map2-5462M Recombinant Mouse Map2 protein, His-tagged Yeast His 213-559aa
Rat Map2-6822R Recombinant Rat Map2 protein, His & GST-tagged E.coli His/GST Thr1459~Arg1718 (Accession # P15146)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Map2 involved in several pathways and played different roles in them. We selected most pathways Map2 participated on our site, such as LKB1 signaling events, MAPK Cascade, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LKB1 signaling eventsCDC37;MAP2;CTSD;STK11IP;SIK3;MARK2;MARK4
MAPK CascadeMBPB;MAP2;MAP3K2;MBP
SIDS Susceptibility PathwaysMECP2;ECE1;SP3;CC2D1A;IL1RN;RUNX3;DLX2;CTCF;PKNOX1

Map2 has several biochemical functions, for example, calmodulin binding, dystroglycan binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2 itself. We selected most functions Map2 had, and list some proteins which have the same functions with Map2. You can find most of the proteins on our site.

Function Related Protein
calmodulin bindingCNGA2;PHKG1B;CAMK2G1;ADCY1;KCNH1;PHKA1;MYH10;MYH1E;RYR1
dystroglycan bindingVCL;AGR3;DMD;GYLTL1B;AGRN;DAG1;AGR2;MAP2;CLASP1
microtubule bindingPAFAH1B1A;KIF21A;MAPRE1A;KIF3A;CHP;MAP1S;KIF18B;NPSNL;GAS2L3
protein bindingAKT3;RNF40;SNTB1;EFEMP2;MAT2B;STT3A;TPR;EWSR1;BAIAP2L1
structural molecule activityCLDNG;ODF2;ISCA1;EPB41L1;KRT8;CLDNI;NEFMA;COPG2;SEPT5

Map2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2.

GRB2; CalpB; JUNB; MDM2; CBFB; SCHIP1; 3',5'-cyclic amp; 8-aha-camp; 8-aha-omethyladenosine; PTBP3; p27958-pro_0000037566

Research Area

Related articles

Cherry, JF; Bennett, NK; et al. Engineered N-cadherin and L1 biomimetic substrates concertedly promote neuronal differentiation, neurite extension and neuroprotection of human neural stem cells. ACTA BIOMATERIALIA 10:4113-4126(2014).
Liang, CM; Weng, SJ; et al. Neurotrophic and neuroprotective potential of human limbus-derived mesenchymal stromal cells. CYTOTHERAPY 16:1371-1383(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How about the possible aspects of future research on MAP2? 10/08/2022

Future research on MAP2 may involve its mechanism of action in neurological diseases, its interaction with other proteins, etc.

What is the relationship between MAP2 and neurological disorders? 08/21/2022

MAP2 may be associated with certain neurological diseases, such as Alzheimer's disease and Parkinson's disease. However, there is still insufficient research on this aspect.

What are some of the current controversies or unresolved issues in the study of MAP2? 11/05/2021

There are still many controversial and unresolved issues in the current research on MAP2, such as its mechanism of action in neurological diseases.

How can the function of MAP2 be studied experimentally? 06/05/2021

The effects of MAP2 on neuronal structure and function, as well as its role in neurological diseases, can be studied through experimental methods such as cell culture and animal models.

How about the distribution of MAP2 in neurons? 02/22/2021

MAP2 is unevenly distributed in neurons and is mainly concentrated in axons and dendrites, with a higher density in dendrites.

How about the relationship between MAP2 and learning Xi and memory? 10/12/2020

The MAP2 may affect the process of learning Xi and memory by affecting the structure and function of neurons. However, there is insufficient research on this aspect.

Customer Reviews (3)

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Reviews
04/11/2023

    I've been using them for several years now and they've been stable and I trust this product a lot.

    02/02/2022

      It is very suitable for biological activity experiments, and the activity is good.

      05/19/2020

        It can meet the needs of daily experiments and has good expression effect.

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