Recombinant Human MAP2 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: MAP2-047H
• Product Overview: MAP2 MS Standard C13 and N15-labeled recombinant protein (NP_002365) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 199.3 kDa
• AA Sequence: MADERKDEAKAPHWTSAPLTEASAH SHPPEIKDQGGAGEGLVRSANGFPY REDEEGAFGEHGSQGTYSNTKENGI NGELTSADRETAEEVSARIVQVVTA EAVAVLKGEQEKEAQHKDQTAALPL AAEETANLPPSPPPSPASEQTVTVE EDLLTASKMEFHDQQELTPSTAEPS DQKEKESEKQSKPGEDLKHAALVSQ PETTKTYPDKKDMQGTEEEKAPLAL FGHTLVASLEDMKQKTEPSLVVPGI DLPKEPPTPKEQKDWFIEMPTEAKK DEWGLVAPISPGPLTPMREKDVFDD IPKWEGKQFDSPMPSPFQGGSFTLP LDVMKNEIVTETSPFAPAFLQPDDK KSLQQTSGPATAKDSFKIEEPHEAK PDKMAEAPPSEAMTLPKDAHIPVVE EHVMGKVLEEEKEAINQETVQQRDT FTPSGQEPILTEKETELKLEEKTTI SDKEAVPKESKPPKPADEEIGIIQT STEHTFSEQKDQEPTTDMLKQDSFP VSLEQAVTDSAMTSKTLEKAMTEPS ALIEKSSIQELFEMRVDDKDKIEGV GAATSAELDMPFYEDKSGMSKYFET SALKEEATKSIEPGSDYYELSDTRE SVHESIDTMSPMHKNGDKEFQTGKE SQPSPPAQEAGYSTLAQSYPSDLPE EPSSPQERMFTIDPKVYGEKRDLHS KNKDDLTLSRSLGLGGRSAIEQRSM SINLPMSCLDSIALGFNFGRGHDLS PLASDILTNTSGSMDEGDDYLPATT PALEKAPCFPVESKEEEQIEKVKAT GEESTQAEISCESPFLAKDFYKNGT VMAPDLPEMLDLAGTRSRLASVSAD AEVARRKSVPSETVVEDSRTGLPPV TDENHVIVKTDSQLEDLGYCVFNKY TVPLPSPVQDSENLSGESGTFYEGT DDKVRRDLATDLSLIEVKLAAAGRV KDEFSVDKEASAHISGDKSGLSKEF DQEKKANDRLDTVLEKSEEHADSKE HAKKTEEAGDEIETFGLGVTYEQAL AKDLSIPTDASSEKAEKGLSSVPEI AEVEPSKKVEQGLDFAVQGQLDVKI SDFGQMASGLNIDDRRATELKLEAT QDMTPSSKAPQEADAFMGVESGHMK EGTKVSETEVKQKVAKPDLVHQEAV DKEESYESSGEHESLTMESLKADEG KKETSPESSLIQDEIAVKLSVEIPC PPAVSEADLATDERADVQMEFIQGP KEESKETPDISITPSDVAEPLHETI VSEPAEIQSEEEEIEAQGEYDKLLF RSDTLQITDLGVSGAREEFVETCPS EHKGVIESVVTIEDDFITVVQTTTD EGESGSHSVRFAALEQPEVERRPSP HDEEEFEVEEAAEAQAEPKDGSPEA PASPEREEVALSEYKTETYDDYKDE TTIDDSIMDADSLWVDTQDDDRSIM TEQLETIPKEEKAEKEARRSSLEKH RKEKPFKTGRGRISTPERKVAKKEP STVSRDEVRRKKAVYKKAELAKKTE VQAHSPSRKFILKPAIKYTRPTHLS CVKRKTTAAGGESALAPSVFKQAKD KVSDGVTKSPEKRSSLPRPSSILPP RRGVSGDRDENSFSLNSSISSSARR TTRSEPIRRAGKSGTSTPTTPGSTA ITPGTPPSYSSRTPGTPGTPSYPRT PHTPGTPKSAILVPSEKKVAIIRTP PKSPATPKQLRLINQPLPDLKNVKS KIGSTDNIKYQPKGGQVQIVTKKID LSHVTSKCGSLKNIGHRPGGGRVKI ESVKLDFKEKAQAKVGSLDNAHHVP GGGNVKIDSQKLNFREHAKARVDHG AEIITQSPGRSSVASPRRLSNVSSS GSINLLESPQLATLAEDVTAALAKQ GLTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MAP2 microtubule associated protein 2 [ Homo sapiens (human) ]
• Official Symbol: MAP2
• Synonyms: MAP2; microtubule associated protein 2; MAP-2; MAP2A; MAP2B; MAP2C; microtubule-associated protein 2
• Gene ID: 4133
• mRNA Refseq: NM_002374
• Protein Refseq: NP_002365
• MIM: 157130
• UniProt ID: P11137

Reviews

04/11/2023

I've been using them for several years now and they've been stable and I trust this product a lot.

02/02/2022

It is very suitable for biological activity experiments, and the activity is good.

05/19/2020

It can meet the needs of daily experiments and has good expression effect.

Q&As

How about the possible aspects of future research on MAP2?

Future research on MAP2 may involve its mechanism of action in neurological diseases, its interaction with other proteins, etc.

What is the relationship between MAP2 and neurological disorders?

MAP2 may be associated with certain neurological diseases, such as Alzheimer's disease and Parkinson's disease. However, there is still insufficient research on this aspect.

What are some of the current controversies or unresolved issues in the study of MAP2?

There are still many controversial and unresolved issues in the current research on MAP2, such as its mechanism of action in neurological diseases.

How can the function of MAP2 be studied experimentally?

The effects of MAP2 on neuronal structure and function, as well as its role in neurological diseases, can be studied through experimental methods such as cell culture and animal models.

How about the distribution of MAP2 in neurons?

MAP2 is unevenly distributed in neurons and is mainly concentrated in axons and dendrites, with a higher density in dendrites.

How about the relationship between MAP2 and learning Xi and memory?

The MAP2 may affect the process of learning Xi and memory by affecting the structure and function of neurons. However, there is insufficient research on this aspect.