Recombinant Human MAP2 protein, His-tagged

• Cat.No.: MAP2-6820H
• Product Overview: Recombinant Human MAP2 aa. (Leu727~Asp985) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Description: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: 43kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Leu727~Asp985
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >98%
• Characteristic: The isoelectric point is 4.7.
• Applications: SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Concentration: 200ug/mL
• Storage buffer: PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
• Reconstitution: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: MAP2 microtubule associated protein 2 [ Homo sapiens (human) ]
• Official Symbol: MAP2
• Synonyms: MAP2A; MAP2B; MAP2C; MAP-2; microtubule-associated protein 2
• Gene ID: 4133
• mRNA Refseq: NM_001039538.1
• Protein Refseq: NP_001034627.1
• UniProt ID: P11137

Reviews

04/11/2023

I've been using them for several years now and they've been stable and I trust this product a lot.

02/02/2022

It is very suitable for biological activity experiments, and the activity is good.

05/19/2020

It can meet the needs of daily experiments and has good expression effect.

Q&As

How about the possible aspects of future research on MAP2?

Future research on MAP2 may involve its mechanism of action in neurological diseases, its interaction with other proteins, etc.

What is the relationship between MAP2 and neurological disorders?

MAP2 may be associated with certain neurological diseases, such as Alzheimer's disease and Parkinson's disease. However, there is still insufficient research on this aspect.

What are some of the current controversies or unresolved issues in the study of MAP2?

There are still many controversial and unresolved issues in the current research on MAP2, such as its mechanism of action in neurological diseases.

How can the function of MAP2 be studied experimentally?

The effects of MAP2 on neuronal structure and function, as well as its role in neurological diseases, can be studied through experimental methods such as cell culture and animal models.

How about the distribution of MAP2 in neurons?

MAP2 is unevenly distributed in neurons and is mainly concentrated in axons and dendrites, with a higher density in dendrites.

How about the relationship between MAP2 and learning Xi and memory?

The MAP2 may affect the process of learning Xi and memory by affecting the structure and function of neurons. However, there is insufficient research on this aspect.