MAP3K12
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Official Full Name
mitogen-activated protein kinase kinase kinase 12 -
Overview
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described. -
Synonyms
MAP3K12;mitogen-activated protein kinase kinase kinase 12;ZPK;DLK;dual leucine zipper kinase DLK;MEKK12;MUK;ZPKP1;protein kinase MUK;MAPK-upstream kinase;mixed lineage kinase;leucine zipper protein kinase;dual leucine zipper bearing kinase
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cells
- Insect Cells
- E.coli
- HEK293
- His
- Flag
- Avi
- Fc
Involved Pathway
MAP3K12 involved in several pathways and played different roles in them. We selected most pathways MAP3K12 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | HRASA,PAK1,MINK1,CACNA2D1A,CACNA1DA,CACNG6,MAPK6,GADD45BB,GRB2,Casp3 |
Protein Function
MAP3K12 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K12 itself. We selected most functions MAP3K12 had, and list some proteins which have the same functions with MAP3K12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | OXSR1A,SGK2A,MAPK14A,RPS6KAL,CDKL2,ACVR2AA,MAP4K6,PPP1R9B,MKNK2B,GRK7A |
| protein serine/threonine kinase activity | CAMK1DB,CSNK1DA,NIM1K,MAP3K14,BRAF,MAP4K1,PRKCQ,STK19,PAK2A,CSNK2A2 |
| protein homodimerization activity | KCNE2,DMRT2B,IL6R,CBX5,TESC,CD226,PRTFDC1,CITED1,WWTR1,ENO2 |
| nucleotide binding | GNAT1,PABPC3,DCLK3,TRMT2A,TIAL1,INSRA,UBE2NB,UBE2G1A,NLRP4C,UBE2KB |
| ATP binding | PLK2,STK32A,ATAD2,CDC34A,TTLL9,TNIK,RIOK2,DDX43,CMPK,ABCC12 |
| MAP kinase kinase kinase activity | MAP3K8,MAP3K4,TAOK1,KIAA1804,MAP3K2,BRAF,MAP3K1,EGFR,ZAK,MAP3K3 |
| transferase activity | EHMT1A,LRGUK,GNPTAB,MARCKSA,SBK1,GGACT.1,UGT1B3,AGXTB,MIBP,PPIP5K2 |
| kinase activity | CDK5R1B,TGFBR1A,STK24B,CDKN1BB,LIMK1A,GSK3B,CAMK2D2,SGK2B,EPHB4A,SBK1 |
| protein kinase binding | PRKAB1,HIF1A,CDC25A,KAT2B,FAF1,NPR1,PTK2,MSN,FGF19,AGAP2 |
Interacting Protein
MAP3K12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K12.
Mapk8ip1;MTOR;SLC16A1;YARS;USP6NL;VWA9;KLF16
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References
- Alghasham, A; Rasheed, Z; et al. Therapeutic targets for rheumatoid arthritis: Progress and promises. AUTOIMMUNITY 47:77-94(2014).
- Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).
