MAP3K12 involved in several pathways and played different roles in them. We selected most pathways MAP3K12 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
GNA12; MAPK11; RPS6KA1; MAP2K2B; PPP3CCA; HSPA1A; PDGFRB; FGFR1; GRB2B; MAPK14A |
MAP3K12 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K12 itself. We selected most functions MAP3K12 had, and list some proteins which have the same functions with MAP3K12. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
DAK; PET112L; ATAD2; PDPK1B; DDX41; CDK15; EPHA3; NLRP9C; ACTR2A; NLK |
| MAP kinase kinase kinase activity |
ALPK2; EGFR; BRAF; TAOK3; MAP3K12; ZAK; MAP3K2; KIAA1804; MAP3K5; RAF1 |
| kinase activity |
PKM; CAMKK1A; BAIAP2L1A; CAMK2D2; INSRA; CAMK1GA; CSNK1G2B; GRK7A; CSNK2A2A; PPIP5K2 |
| nucleotide binding |
ABCA5; ACTC1B; MAPK14A; RHOT1A; RHOU; A1CF; PTBP1; HNRNPA0; RAB42B; SFRS3A |
| protein homodimerization activity |
GNPTG; CDSN; HEXB; RASGRP1; BCL2A1A; UGT1A3; ROPN1B; SYT10; GRPEL1; SEPT12 |
| protein kinase activity |
CAMK1GA; SIK2A; SGK196; PTK2AB; BMPR1AB; RNASEL; SCYL2; EPHA4A; PAK2; SRPK1B |
| protein kinase binding |
PTPN23; Cd24a; ILK; FAM83D; PTPRC; TMEM173; PPME1; MAP3K2; PPP1R12B; PKD1 |
| protein serine/threonine kinase activity |
CSNK1A1; STK35L; GRK1A; TLK2; PRKD1; PDPK1; ERN2; MAP2K3; CAMK1GA; RPS6KA3B |
| transferase activity |
HHAT; HS2ST1A; FTSJD2; UGT2B1; LYCAT; LIPT2; BMPR1BA; PKMB; UGT5A2; MAPK8A |
MAP3K12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K12.
Mapk8ip1; MTOR; SLC16A1; YARS; USP6NL; VWA9; KLF16
Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).
Alghasham, A; Rasheed, Z; et al. Therapeutic targets for rheumatoid arthritis: Progress and promises. AUTOIMMUNITY 47:77-94(2014).
