MAP3K12

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 12

  • Overview

    This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
  • Synonyms

    MAP3K12; mitogen-activated protein kinase kinase kinase 12; ZPK; DLK; dual leucine zipper kinase DLK; MEKK12; MUK; ZPKP1; protein kinase MUK; MAPK-upstream kinase; mixed lineage kinase; leucine zipper protein kinase; dual leucine zipper bearing kinase;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K12-41H Recombinant Human MAP3K12 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human MAP3K1214285H Recombinant Human MAP3K12 (103-470) Protein
Mouse MAP3K12-9508M Recombinant Mouse MAP3K12 Protein Mammalian Cell His
Mouse MAP3K12-5329M-B Recombinant Mouse MAP3K12 Protein Pre-coupled Magnetic Beads HEK293
Mouse MAP3K12-5329M Recombinant Mouse MAP3K12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAP3K12-3565R Recombinant Rat MAP3K12 Protein Mammalian Cell His
Rat Map3k12-1758R Recombinant Rat Map3k12 Protein, His-tagged E.coli N-His
Rat MAP3K12-3221R Recombinant Rat MAP3K12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAP3K12-3221R-B Recombinant Rat MAP3K12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MAP3K12-2667R Recombinant Rhesus monkey MAP3K12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAP3K12-2487R Recombinant Rhesus Macaque MAP3K12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAP3K12-2487R-B Recombinant Rhesus Macaque MAP3K12 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAP3K12-11822Z Recombinant Zebrafish MAP3K12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP3K12 Related Articles

MAP3K12 involved in several pathways and played different roles in them. We selected most pathways MAP3K12 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayNF1;FGFR1;PPP3R2;TGFBR2;PPP5C;CACNG6;TRP53;MAP4K4;FGF6B

MAP3K12 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K12 itself. We selected most functions MAP3K12 had, and list some proteins which have the same functions with MAP3K12. You can find most of the proteins on our site.

Function Related Protein
ATP bindingAMHR2;LATS2;MYO3B;ABCB6A;FYNA;UBA1;FIGN;CFTR;PFKM
MAP kinase kinase kinase activityMAP3K14;MAP3K5;TAOK1;MOS;MAP3K3;MAP3K13;RAF1;MAP3K1;MAP3K8
kinase activityCAMKK1A;PRKG1A;EGFRA;NEK4;NIM1;NME2B.2;SRPK1B;PRKAR1AA;MIBP
nucleotide bindingRHOAA;ARL15A;RASEF;STK24B;MYO7AA;PKZ;TINAG;ARF3B;PRKG1A
protein homodimerization activityCLN6;HOMER2;CHUK;ACTN1;SUMF1;TPD52L2;FOXP3;TREX1;ATIC
protein kinase activityGSK3AB;PRKCBA;TGFBR1B;TRIM28;NEK4;GUCY2F;PDK3;MAPK14B;PTK2AA
protein kinase bindingGYS1;CCND2;DNM1;MAPK8IP2;KIF20A;BCL2L14;ACVRL1;CDK5RAP2;AGAP2
protein serine/threonine kinase activityADCK1;PRKCA;PAK1;NEK1;RAF1B;TAOK3;MAP3K4;CASK;ACVR2AA
transferase activityPI4KAA;FUT9B;GGT1A;RAF1B;Acnat1;STK38A;SULT1D1;CDKN1D;Art2b

MAP3K12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K12.

Mapk8ip1; MTOR; SLC16A1; YARS; USP6NL; VWA9; KLF16

Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).
Alghasham, A; Rasheed, Z; et al. Therapeutic targets for rheumatoid arthritis: Progress and promises. AUTOIMMUNITY 47:77-94(2014).
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