MAP3K6
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Official Full Name
mitogen-activated protein kinase kinase kinase 6 -
Overview
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. -
Synonyms
MAP3K6;mitogen-activated protein kinase kinase kinase 6;apoptosis signal regulating kinase 2;ASK2;MAPKKK6;MEKK6;apoptosis signal-regulating kinase 2;MGC20114;MGC125653
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAP3K6-1429H |
Active Recombinant Human MEKK6, GST-tagged
|
Sf9 Cells | Human | GST | 620-950 aa |
|
| Map3k6-8082R | Recombinant Rat Map3k6 protein, His & T7-tagged | E.coli | Rat | His&T7 | Thr649~Leu907 |
|
| MAP3K6-9516M | Recombinant Mouse MAP3K6 Protein | Mammalian Cells | Mouse | His |
|
|
| MAP3K6-5334M | Recombinant Mouse MAP3K6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
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| MAP3K6-5334M-B | Recombinant Mouse MAP3K6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
MAP3K6 involved in several pathways and played different roles in them. We selected most pathways MAP3K6 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | BDNF,MAPK8IP2,CDC42L2,NTRK2B,TGFB1A,GADD45BA,MEF2CB,CACNA2D2,RAP1B,GADD45G |
Protein Function
MAP3K6 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K6 itself. We selected most functions MAP3K6 had, and list some proteins which have the same functions with MAP3K6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase kinase kinase activity | MAP3K12,TAOK2,MAP3K3,ALPK2,STK4,KIAA1804,MAP3K13,MAP3K15,MAP3K2,MAP3K1 |
| magnesium ion binding | PDXP,NEK6,MTPAP,TSSK2,PGM1,ENO1,ILVBL,LATS1,TESC,IDH1 |
| ATP binding | ABCC6,HLCS,PRKACAB,ATP10A,DDX18,IPPK,ACTR1B,IPMK,TOR2A,ERCC6L |
Interacting Protein
MAP3K6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K6.
MAP3K5;PRKAB2;HSP90AB1;PRKAA2;glcD3;asnO3;YWHAG
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References
- Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
- Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).
