|Official Full Name||TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1|
|Background||The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.|
|Synonyms||3'-Tab1; MGC57664; MAP3K7IP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; OTTHUMP00000199134; OTTHUMP00000199135; TAK1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1|
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map3k7ip1 involved in several pathways and played different roles in them. We selected most pathways map3k7ip1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with map3k7ip1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
map3k7ip1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by map3k7ip1 itself. We selected most functions map3k7ip1 had, and list some proteins which have the same functions with map3k7ip1. You can find most of the proteins on our site.
map3k7ip1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map3k7ip1 here. Most of them are supplied by our site. Hope this information will be useful for your research of map3k7ip1.