• Official Full Name

    mitogen-activated protein kinase kinase kinase 8

  • Background

    This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
  • Synonyms

    MAP3K8; mitogen-activated protein kinase kinase kinase 8; COT, ESTF; c COT; EST; MEKK8; Tpl 2; proto-oncogene c-Cot; tumor progression locus 2; Ewing sarcoma transformant; cot (cancer Osaka thyroid) oncogene; proto-oncogene serine/threoine protein kinase;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K8-29126TH Recombinant Human MAP3K8 N/A
    Human MAP3K8-572H Active Recombinant Human MAP3K8, GST-tagged Sf9 Insect Cell GST
    Human MAP3K8-29813TH Recombinant Human MAP3K8 N/A
    Human MAP3K8-988H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 8, GST-tagged Sf9 Insect Cell GST
    Human MAP3K8-629HCL Recombinant Human MAP3K8 cell lysate Insect Cell N/A
    Human MAP3K8-957H Recombinant Human MAP3K8, GST tagged Insect Cell GST
    Human MAP3K8-636H Recombinant Human MAP3K8, GST-His Sf9 Insect Cell GST
    Mouse MAP3K8-5335M-B Recombinant Mouse MAP3K8 Protein Pre-coupled Magnetic Beads HEK293
    Mouse MAP3K8-5335M Recombinant Mouse MAP3K8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse MAP3K8-9518M Recombinant Mouse MAP3K8 Protein Mammalian Cell His
    Rat MAP3K8-3223R-B Recombinant Rat MAP3K8 Protein Pre-coupled Magnetic Beads HEK293
    Rat MAP3K8-3567R Recombinant Rat MAP3K8 Protein Mammalian Cell His
    Rat MAP3K8-3223R Recombinant Rat MAP3K8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAP3K8 Related Research Area

    MAP3K8 involved in several pathways and played different roles in them. We selected most pathways MAP3K8 participated on our site, such as Activated TLR4 signalling, Adaptive Immune System, CD28 co-stimulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signallingCREB1;PELI1;DUSP7;S100B;APPB;PELI2;UBE2V1;TANK;TNIP2
    Adaptive Immune SystemAP2A2;FRS2A;KLRG1;RNF138;KIFAP3;ASB11;NPEPPS;ASB8;SPSB4
    CD28 co-stimulationPDPK1A;THEM4;MAP3K8;MAPKAP1
    CD28 dependent PI3K/Akt signalingTHEM4;PDPK1A;MAP3K8;MAPKAP1
    Costimulation by the CD28 familyTHEM4;HLA-DQB2;MAPKAP1;MAP3K8;CTLA4;PDPK1A;BTLA;CSK
    Cytokine Signaling in Immune systemTRIM29;DUSP6;TRIM14;SPTBN1;FGF8B;CASPB;SPTBN2;TRIM48;DAB2IPB
    Immune SystemFCN1;TRAF7;RNF182;UFL1;CSH1;ASB10;CLEC2H;SIGLEC10;IFI16
    Innate Immune SystemNLRP4;CLEC6A;POLR3G;LRRFIP1;UNC93B1;MGC174155;DEFB129;TLR6;NLRP4E

    MAP3K8 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K8 itself. We selected most functions MAP3K8 had, and list some proteins which have the same functions with MAP3K8. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase activityRAF1;MAP3K5;YSK4;MAP3K8;MAP3K3;BRAF;ZAK;MAP3K2;MAP3K13
    protein serine/threonine kinase activityWNK1;OBSCN;LMTK3;NIM1;CDK1;ACVR2AA;MAP2K2A;STK25;MAP2K3

    MAP3K8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K8.

    NFKB1; TNIP2

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