MAP3K8
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Official Full Name
mitogen-activated protein kinase kinase kinase 8 -
Overview
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. -
Synonyms
MAP3K8;mitogen-activated protein kinase kinase kinase 8;COT, ESTF;c COT;EST;MEKK8;Tpl 2;proto-oncogene c-Cot;tumor progression locus 2;Ewing sarcoma transformant;cot (cancer Osaka thyroid) oncogene;proto-oncogene serine/threoine protein kinase
Recombinant Proteins
- Human
- Rat
- Mouse
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- HEK293
- GST
- Non
- His
- Avi
- Fc
Involved Pathway
MAP3K8 involved in several pathways and played different roles in them. We selected most pathways MAP3K8 participated on our site, such as Activated TLR4 signalling,Adaptive Immune System,CD28 co-stimulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CD28 co-stimulation | PDPK1A,MAPKAP1,THEM4 |
| Immune System | FBXO17,PPAPDC1A,AP1S1,RCA2.1,LTN1,PRLRB,BTR18,IFI6,FBXO3,SIGLEC6 |
| Cytokine Signaling in Immune system | OASL,IRF2,IRF4,IL1RN,RASGEF1A,TRIM8,DUSP1,OSTN,PTPRA,CRKL |
| Adaptive Immune System | CLEC2G,FAM49BA,CTSH,CD300LD,ASB11,RASGRP1,FGF18B,NPEPPS,STIM1B,EVL |
| Activated TLR4 signalling | CREB1,RIPK3,APPA,TNIP2,SAA1,DUSP4,PELI2,PELI1,MAPK14,SIGIRR |
| Innate Immune System | DEFB4A,NLRP4,SIRPB1,SIGLEC14,FCN1,ABI1B,WIPF2,NOD1,TRIM56,TAX1BP1 |
| CD28 dependent PI3K/Akt signaling | PDPK1A,THEM4,MAPKAP1 |
| Costimulation by the CD28 family | BTLA,MAPKAP1,CSK,HLA-DQB2,PDPK1A,CTLA4,THEM4 |
Protein Function
MAP3K8 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K8 itself. We selected most functions MAP3K8 had, and list some proteins which have the same functions with MAP3K8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | CDK5,CDKL5,BMPR1AA,TP53RK,LIMK1,GRK7A,DCLK3,BMPR2A,GRK5,PRKCHB |
| magnesium ion binding | STK38,CERK,PGM3,ENO1,ATP11A,DUT,NCS1,TSSK2,THTPA,ATP8B3 |
| ATP binding | CAMK2A,UBA2,CMPK2,DNAH5,ACSS1,MAST2,FYN,KITB,MAPKAPK2B,PIK3CB |
| MAP kinase kinase kinase activity | MAP3K4,EGFR,MAP3K3,BRAF,STK4,MAP3K13,MAP3K2,MOS,ZAK,MAP3K12 |
| protein binding | STK3,DDI1,SNX3,ARID1A,UVRAG,RFX1,IRAK1BP1,CST9L,LRCH1,CNBP |
Interacting Protein
MAP3K8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K8.
NFKB1;TNIP2
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