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MAPK4

  • Official Full Name

    mitogen-activated protein kinase 4

  • Overview

    Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region. However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, poss Encodes a nuclear and cytoplasmically localized MAP kinase involved in mediating responses to pathogens. Its substrates include MKS1 and probably MAP65-1.The MAP65-1 interaction is involved in mediating cortical microtuble organization.
  • Synonyms

    MAPK4; mitogen-activated protein kinase 4; PRKM4; Erk3 related; Erk4; ERK-4; MAPK 4; p63-MAPK; Erk3-related; MAP kinase 4; MAP kinase isoform p63; extracellular signal-regulated kinase 4; ERK3; p63MAPK; MPK4; ATMPK4; MAP kinase 4 (MPK4); FUNCTIONS IN: MAP kinase activity, kinase activity; INVOLVED IN: in 14 processes; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), JNK MAP kinase (InterPro:IPR008351), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: MAP kinase 11 (TAIR:AT1G01560.2); Has 123445 Blast hits to 122024 proteins in 4656 species: Archae - 100; Bacteria - 13145; Metazoa - 47072; Fungi - 12439; Plants - 29862; Viruses - 477; Other Eukaryotes - 20350 (source: NCBI BLink).; F2N1.1; F2N1_1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • GST
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK4-4493HCL Recombinant Human MAPK4 293 Cell Lysate HEK293 N/A
Human MAPK4-0111H Recombinant Human MAPK4 Protein (A2-W587), His/GST tagged Insect Cell His/GST A2-W587
Human MAPK4-2276H Recombinant Human MAPK4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK4-0110H Recombinant Human MAPK4 Protein (A2-W587), Tag Free Insect Cell No tag A2-W587
Mouse MAPK4-9535M Recombinant Mouse MAPK4 Protein Mammalian Cell His
Mouse Mapk4-3943M Recombinant Mouse Mapk4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAPK4-5351M Recombinant Mouse MAPK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAPK4-5351M-B Recombinant Mouse MAPK4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MAPK4-2673R Recombinant Rhesus monkey MAPK4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAPK4-2493R Recombinant Rhesus Macaque MAPK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAPK4-2493R-B Recombinant Rhesus Macaque MAPK4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAPK4-12640Z Recombinant Zebrafish MAPK4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MAPK4 involved in several pathways and played different roles in them. We selected most pathways MAPK4 participated on our site, such as B Cell Receptor Signaling Pathway, Focal Adhesion, Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
B Cell Receptor Signaling PathwayPPP3R2;DUSP6;CR2;CSK;PLEKHA2;CRKL;PIK3R2;IKBKG;LILRB3
Focal AdhesionTNC;SPP1;RAF1;ARHGAP35;MAPK1;PAK4;RAP1AB;MYL2;MYL12A
Insulin SignalingSTXBP3A;GSK3AB;STXBP2;FLOT1;KIF5B;EHD1;MAPK4;ARHGAP33;MAP3K10
Integrated Pancreatic Cancer PathwayMYT1;CD82;WRN;TOP1;CASP12;PPP1R13L;IL11;JUND;AGA
Integrin-mediated cell adhesionMAPK6;SEPP1A;CAPNS1;CAPN9;TNS1;CAPN11;CAPN3A;CAPN10;CAPN5
MAPK family signaling cascadesCDC42EP1B;CDC42EP5;SEPT7;MAPK6;CDC42EP3;CDC42EP2;MAPK4;IGF2BP1
MAPK signaling pathwayFGF12A;FGF17;MAP3K5;FGF11A;CACNG7A;PLA2G4C;RAF1B;MAPKAPK5;FGFR2
MAPK6/MAPK4 signalingMAPK4;SEPT7;IGF2BP1;CDC42EP5;CDC42EP1B;MAPK6;CDC42EP3;CDC42EP2

MAPK4 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK4 itself. We selected most functions MAPK4 had, and list some proteins which have the same functions with MAPK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPIP4K2B;MYH1E;MCM8;UBE2E1;RYK;ABCC10;ACACA;VWA8;MCM3
MAP kinase activityMAPK13;MAPK12B;MAPK6;NLK2;MAPK14;MAPK15;MAPK1;MAPK14A;MAPK7
protein bindingHSD17B10;CALM2;FOXN3;CAMK2A;C1QA;MPP1;ST6GAL1;FAM46D;DIEXF
protein heterodimerization activityHIST1H3F;TTR;HIST1H2BO;DRD1;TLR1;BTBD11A;POLE3;HIST1H3A;SOX32
protein homodimerization activityRENBP;MFF;PVRL1B;NOG;MCL1B;PAH;TREX1;PRKG2;MECOM
protein kinase bindingPARP1;CAMK2N2;CALM1;USP37;ERRFI1;AGTR1A;CALM;ADCY6;SPDYA
protein serine/threonine kinase activityIRAK1;NUAK2;HUNK;RAF1B;STK17A;PRKCA;SBK3;GRK1B;RIOK3

MAPK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK4.

HSP90AB1; CALML3; CRK; PSMA7; ATP1A1; PFKP; FASTKD5; ERC1; MAPKAPK5; FAM57A; TECR

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