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Official Full Name mitogen-activated protein kinase 6
Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Encodes a MAP kinase induced by pathogens, ethylene biosynthesis, oxidative stress and osmotic stress.Also involved in ovule development. Homozygous mutants in a MPK3 heterozygous background are female sterile due to defects in integument development.MPK6 appears to be associated with the microsomal compartment and may be involved in mediating secretory processes.
Synonyms MAPK6; mitogen-activated protein kinase 6; PRKM6; ERK3; HsT17250; p97MAPK; ERK-3; MAPK 6; p97-MAPK; MAP kinase 6; MAP kinase isoform p97; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6; extracellular signal-regulated kinase 3; ex; MPK6; Arabidopsis thaliana MPK6; AtMPK6; MAP kinase 6 (MPK6); FUNCTIONS IN: MAP kinase activity, kinase activity; INVOLVED IN: in 20 processes; LOCATED IN: trans-Golgi network, preprophase band, phragmoplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), JNK MAP kinase (InterPro:IPR008351), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase 3 (TAIR:AT3G45640.1); Has 124968 Blast hits to 123484 proteins in 4565 species: Archae - 94; Bacteria - 13025; Metazoa - 47222; Fungi - 12634; Plants - 30512; Viruses - 574; Other Eukaryotes - 20907 (source: NCBI BLink).; ATMAPK6; F18O19.10
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK6-284H Recombinant Human MAPK6 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK6-285H Recombinant Human MAPK6 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK6-4492HCL Recombinant Human MAPK6 293 Cell Lysate HEK293 N/A
    Human MAPK6-644H Recombinant Human MAPK6 Protein (1-721 aa), His-SUMO-tagged E.coli His/SUMO
    Human MAPK6-659H Recombinant Human MAPK6 Protein, His-tagged E.coli His
    Human MAPK6-742H Recombinant Human MAPK6, GST-tagged E.coli GST
    Mouse MAPK6-9536M Recombinant Mouse MAPK6 Protein Mammalian Cell His
    Rat MAPK6-3575R Recombinant Rat MAPK6 Protein Mammalian Cell His
    Chicken MAPK6-2263C Recombinant Chicken MAPK6 Mammalian Cell His
    Zebrafish MAPK6-4420Z Recombinant Zebrafish MAPK6 Mammalian Cell His

    MAPK6 involved in several pathways and played different roles in them. We selected most pathways MAPK6 participated on our site, such as Focal Adhesion, Insulin Signaling, Integrin-mediated cell adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Focal Adhesion MYL12.2; PAK1; LAMC3; BRAF; VEGFC; GRB2; ITGA2B; LAMB3; HRAS; PDGFA
    Insulin Signaling GRB14; MAP3K9; MAP4K1; INPP4AA; MYO1C; RRAD; STXBP2; STXBP3A; RHOJ; MAP3K2
    Integrin-mediated cell adhesion CAPN3; CAPN9; CAPN5; TNS1; MAPK6; CAPN3A; CAPN10; CAPN11; MYLK2; SEPP1A
    MAPK family signaling cascades CDC42EP5; CDC42EP1B; CDC42EP2; MAPK6; SEPT7; IGF2BP1; CDC42EP3; MAPK4
    MAPK6/MAPK4 signaling CDC42EP5; SEPT7; MAPK6; IGF2BP1; MAPK4; CDC42EP3; CDC42EP2; CDC42EP1B
    Regulation of Actin Cytoskeleton PAK6; INS; ITGB1A; ARPC5L; PTK2; ITGA4; GNA12; INS2; RDX; FGF16
    Signal Transduction UCHL5; CCL35.2; DHRS3; ARHGEF1B; MYO7A; TAGAPA; APLN; TLE3B; IQCE; NMT1B

    MAPK6 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK6 itself. We selected most functions MAPK6 had, and list some proteins which have the same functions with MAPK6. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SYN1; YES1; HCK; ADCY9; INSR; HSP90AA1.2; ATP2A3; ACSL3; ATP8A1; ACACB
    MAP kinase activity NLK; MAPK15; MAPK12A; MAPK8A; MAPK14B; NLK1; MAPK14; MAPK13; MAPK6; MAPK11
    protein binding PTPRO; EXOC1; RCOR1; TCERG1; SCG2; Shh; FMNL1; TTLL6; EIF2S3; IGFBP2
    protein heterodimerization activity TIRAP; CYBB; USF1; BNIP3; NFKB1; TAF12; POLA1; ATF6; BDKRB2; ZFP423
    protein kinase binding SUFU; B4GALT1; CDKN2A; GSTP2; CEP68; FER; GATA4; PFKFB2; GCSAM; CDH2
    protein serine/threonine kinase activity STK11; PIM2; TTBK2; TESK1; ACVR2A; TGFBR1; MELK; PLK2; TSSK6; PKN2

    MAPK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK6.


    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).

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