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MAPK8IP2

Official Full Name

mitogen-activated protein kinase 8 interacting protein 2
Overview

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Synonyms

MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2; PRKM8 interacting protein like , PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; IB2; islet brain 2; JIP2; JNK interacting protein 2; IB-2; JIP-2; islet-brain 2; islet-brain-;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAPK8IP2-29843TH	Recombinant Human MAPK8IP2, His-tagged	E.coli	His		Inquiry
Human	MAPK8IP2-402HCL	Recombinant Human MAPK8IP2 lysate	HEK293	N/A		Inquiry
Human	MAPK8IP2-384H	Recombinant Human MAPK8IP2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	MAPK8IP2-6302H	Recombinant Human MAPK8IP2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MAPK8IP2-301565H	Recombinant Human MAPK8IP2 protein, GST-tagged	E.coli	GST	Thr41-Lys135	Inquiry
Mouse	Mapk8ip2-3947M	Recombinant Mouse Mapk8ip2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MAPK8IP2 involved in several pathways and played different roles in them. We selected most pathways MAPK8IP2 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8IP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	BRAF;CACNB3A;NTRK2B;CACNA1B;MAP2K3;CDC42;MAPK8A;Casp3;CDC42L2

MAPK8IP2 has several biochemical functions, for example, MAP-kinase scaffold activity, beta-amyloid binding, kinesin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8IP2 itself. We selected most functions MAPK8IP2 had, and list some proteins which have the same functions with MAPK8IP2. You can find most of the proteins on our site.

Function	Related Protein
MAP-kinase scaffold activity	KSR1;JIP1;MAPK8IP3;DUSP19;SPAG9;CD36;MAPK8IP2;SPAG9A
beta-amyloid binding	APOEB;CLSTN1;CST3;ARMCX5-GPRASP2;BACE2;NGFR;TM2D1;COL25A1;APBB1
kinesin binding	PIFO;KIAA1279;JAKMIP1;AP1G1;ARHGEF10;SPAG9A;GOLSYN;MAPK8IP2;SNCA
protein binding	USO1;PPM1B;ZNRF1;GNG10;ANKFY1;TOR1AIP1;ST6GAL1;SYT4;WHSC1L1
protein complex binding	HADHA;FYB;ABP1;RARB;NDUFA4;MYC;NRAS;TELO2;VDAC1
protein kinase activator activity	CAB39;FGF13;STRADA;NKX3;DAXX;GPRC5B;PIK3CA;WNT11;MT3
protein kinase binding	GRB2;SFN;RNF138;ITGB2;CALM2;PIH1D1;NPR1;PTPN6;MEF2A
structural molecule activity	COPE;ASPH;KRT84;KRTAP3-1;LAD1;KRT25;CLDN6;CLDN10B;IVL

MAPK8IP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8IP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8IP2.

EGFR; UBD; ANGPT1; q53hf2_human; IGIP; TMEM128; C22orf39; C8orf33