MAPK8IP2 Protein


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Official Full Name mitogen-activated protein kinase 8 interacting protein 2
Background The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Synonyms MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2; PRKM8 interacting protein like , PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; IB2; islet brain 2; JIP2; JNK interacting protein 2; IB-2; JIP-2; islet-brain 2; islet-brain-
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK8IP2-29843TH Recombinant Human MAPK8IP2, His-tagged E.coli His
    Human MAPK8IP2-402HCL Recombinant Human MAPK8IP2 lysate HEK293 N/A
    Human MAPK8IP2-301565H Recombinant Human MAPK8IP2 protein, GST-tagged E.coli GST
    Human MAPK8IP2-384H Recombinant Human MAPK8IP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAPK8IP2-6302H Recombinant Human MAPK8IP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Mapk8ip2-3947M Recombinant Mouse Mapk8ip2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAPK8IP2 involved in several pathways and played different roles in them. We selected most pathways MAPK8IP2 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8IP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNG7A; MAPK12; FGF14; HSPA1L; GNA12; GNA12A; RAC3A; PRKACAA; TGFBR1; CASP3A

    MAPK8IP2 has several biochemical functions, for example, MAP-kinase scaffold activity, beta-amyloid binding, kinesin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8IP2 itself. We selected most functions MAPK8IP2 had, and list some proteins which have the same functions with MAPK8IP2. You can find most of the proteins on our site.

    Function Related Protein
    MAP-kinase scaffold activity CD36; MAPK8IP2; KSR1; JIP1; SPAG9; SPAG9A; DUSP19; MAPK8IP3
    beta-amyloid binding APOE; APBB3; APOA1; TSSK1B; FBXO2; MAPK8IP2; OLFM1; CLSTN1; APOEB; ARMCX5-GPRASP2
    kinesin binding AP1AR; AP1G1; GOLSYN; ATCAY; DISC1; SPAG9A; PRC1; KIFAP3; KIAA1279; PIFO
    protein binding HELZ2; FRS2; ROCK2; CAMK2D; GJA4; ID1; ITPKB; USP8; CHMP6; POP1
    protein complex binding TAPBPL; KRT8; LRRC16A; NASP; MTHFR; ATP6V1B1; TRAF2; PTK2B; MYC; MTAP1B
    protein kinase activator activity GPRC5B; DAXX; NCKAP1L; STRADA; MT3; NKX3; NKX3-1; DUSP19; STK11; PIK3CA
    protein kinase binding ATG13; MAPKAP1; TPX2; NCS1; CCNL2; PLCG1; GYS1; MAP3K5; PDCD10; IL12RB2
    structural molecule activity LAMA5; NES; GNL1; MTAP7D2; KRT4; LAMA2; FLG2; LAD1; FGB; COPG

    MAPK8IP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8IP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8IP2.

    EGFR; UBD; ANGPT1; q53hf2_human; IGIP; TMEM128; C22orf39; C8orf33

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