MAPK8IP3
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Official Full Name
mitogen-activated protein kinase 8 interacting protein 3 -
Overview
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. -
Synonyms
MAPK8IP3;mitogen-activated protein kinase 8 interacting protein 3;C-Jun-amino-terminal kinase-interacting protein 3;homolog of Drosophila Sunday driver 2;JIP3;JSAP1;KIAA1066;syd;FLJ00027;JNK / Stress Activated Protein Kinase Associated Protein 1;JNK Interacting Protein 3;Mitogen Activated Protein kinase 8 Interacting Protein 3;JIP-3;JNK-interacting protein 3;JNK/SAPK-associated protein-1;JNK MAP kinase scaffold protein 3;C-jun-amino-terminal kinase interacting protein 3;JNK/stress-activated protein kinase-associated protein 1;mitogen-activated protein kinase 8-interacting protein 3;SYD2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAPK8IP3-8491Z | Recombinant Zebrafish MAPK8IP3 | Mammalian Cells | Zebrafish | His |
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| MAPK8IP3-9541M | Recombinant Mouse MAPK8IP3 Protein | Mammalian Cells | Mouse | His |
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| MAPK8IP3-5354M | Recombinant Mouse MAPK8IP3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MAPK8IP3-5354M-B | Recombinant Mouse MAPK8IP3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MAPK8IP3 involved in several pathways and played different roles in them. We selected most pathways MAPK8IP3 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8IP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAX,RAP1A,GADD45AA,HRASA,RAC3A,CACNG8,TP53,FGF10A,RPS6KA3B,MAP4K3 |
Protein Function
MAPK8IP3 has several biochemical functions, for example, JUN kinase binding,MAP-kinase scaffold activity,kinesin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8IP3 itself. We selected most functions MAPK8IP3 had, and list some proteins which have the same functions with MAPK8IP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mitogen-activated protein kinase kinase binding | TRIB1,MAP3K11,TRIB2,TRIB3,PIN1,TAOK2,RAF1,BRAF,KSR1,IGBP1 |
| MAP-kinase scaffold activity | JIP1,SPAG9A,DUSP19,SPAG9,MAPK8IP2,CD36,KSR1 |
| kinesin binding | KIF1B,IFT88,NUP62,ARPC2,KLC2,CLSTN1,SNCA,ACTB,PRC1,SYBU |
| JUN kinase binding | SPAG9,MAD2L2,SPAG9A,GSTP1,PTK2 |
| protein binding | WDR92,CHTOP,POLA1,CRABP2,KIAA0247,EIF3M,MSR1,DALRD3,CD79A,CLNS1A |
| mitogen-activated protein kinase kinase kinase binding | MARVELD3,MAP4K2,TRAF6,CDC37,STK38,DUSP19,MAP3K11,TRAF2,CDC42,MAPK9 |
| receptor signaling complex scaffold activity | CARD10,LDLRAP1,NCK2,SHANK1,G3BP2,GRIP1,DEDD2,SPAG9A,LRRK2,AXIN1 |
Interacting Protein
MAPK8IP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8IP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8IP3.
Klc1;Klc2;Arf6
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References
- Gunawardhana, LP; Baines, KJ; et al. Differential DNA Methylation Profiles of Infants Exposed to Maternal Asthma During Pregnancy. PEDIATRIC PULMONOLOGY 49:852-862(2014).
- Cho, IH; Lee, KW; et al. JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains. EXPERIMENTAL AND MOLECULAR MEDICINE 43:462-470(2011).
