MARCH6
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Official Full Name
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase -
Synonyms
MARCH6;membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase;30550;ENSG00000145495;TEB4;DOA10;RNF176;MARCH-VI;5p15.2;KIAA0597, DKFZp586L081;E3 ubiquitin-protein ligase MARCH6;E3 ubiquitin-protein ligase MARCH6;doa10 homolog;RING finger protein 176;membrane-associated RING-CH protein VI;membrane-associated RING finger protein 6;membrane-associated RING-CH finger protein 6;EC 6.3.2.-
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MARCH6-8444Z | Recombinant Zebrafish MARCH6 | Mammalian Cells | Zebrafish | His |
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| MARCH6-9559M | Recombinant Mouse MARCH6 Protein | Mammalian Cells | Mouse | His |
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| MARCH6-5367M | Recombinant Mouse MARCH6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MARCH6-5367M-B | Recombinant Mouse MARCH6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MARCH6 involved in several pathways and played different roles in them. We selected most pathways MARCH6 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | UBE2D2L,HNF4B,CRYAB,PDIA3,CAPN2,PDIP5,DNAJC3,TUSC3,GANAB,DERL1 |
Protein Function
MARCH6 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCH6 itself. We selected most functions MARCH6 had, and list some proteins which have the same functions with MARCH6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TRIM50,SIAH2,ITCH,BRAP,UBE2D1B,MKRN2,UBE3A,UBE2IA,CPS1,RNF146 |
| metal ion binding | MAT2AL,GFI1B,ZBTB8A,EGR2,NEK1,ZFP423,PON3,CTH1,LHX1B,ZBTB2B |
| tubulin-glutamic acid ligase activity | RNF169,ARIH1L,TRIM41,ZNRF3,RAG1,RNF144AA,UBE2IB,MGRN1A,SIAH2L,MARCH5L |
| protein-glycine ligase activity, elongating | RC3H2,RNF187,LTN1,ZNRF2B,TRIM50,UBE2IB,TMEM129,RNF149,MARCH11,TRIM41 |
| ribosomal S6-glutamic acid ligase activity | UBE2IA,SIAH1A,MARCH5L,MYLIPA,DTX1,MARCH11,RAG1,RNF187,MYLIPB,TRIM41 |
| enzyme binding | MSH3,GOLPH3,WWOX,CABYR,RAD9,MAPK8,HDAC1,HMGA1-RS1,SIRT1,Il6ra |
| ubiquitin-specific protease binding | SART3,SELS,VCP,VPS24,PARK2,SYVN1,RAD23A,AMFR,BAG6,PARK7 |
| coenzyme F420-2 alpha-glutamyl ligase activity | G2E3,SHRPRBCK1R,ZNRF2B,MARCH11,UBR1,MARCH5L,MARCH4,TRIM50,NEURL3,TRIM71 |
| protein-glutamic acid ligase activity | TMEM129,SHRPRBCK1R,RFWD2,TRIM50,RNF144AB,RAG1,ZNRF3,UBR1,MARCH9,NEURL3 |
Interacting Protein
MARCH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCH6.
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References
- Nakamura, N; Harada, K; et al. Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6. EXPERIMENTAL CELL RESEARCH 328:207-216(2014).
- Egri, P; Gereben, B; et al. Minimal requirements for ubiquitination-mediated regulation of thyroid hormone activation. JOURNAL OF MOLECULAR ENDOCRINOLOGY 53:217-226(2014).
