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MARK4

  • Official Full Name

    MAP/microtubule affinity-regulating kinase 4

  • Overview

    Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (
  • Synonyms

    MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity regulating kinase like 1 , MARKL1; FLJ90097; KIAA1860; Nbla00650; MARK4 serine/threonine protein kinase; MAP/microtubule affinity-regulating kinase like 1; MARK4L; MARK4S; MARKL;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Insect (sf21)
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MARK4-1058H Recombinant Human MAP/Microtubule Affinity-Regulating Kinase 4, GST-tagged Sf9 Insect Cell GST
Human MARK4-29129TH Recombinant Human MARK4 Sf9 Insect Cell N/A 752 amino acids
Human MARK4-4464HCL Recombinant Human MARK4 293 Cell Lysate HEK293 N/A
Human MARK4-1361HF Active Recombinant Full Length Human MARK4 Protein, GST-tagged Insect (sf21) GST 1-688
Human MARK4-1199H Recombinant Human MARK4 Protein (N44-K370), His tagged E.coli His N44-K370
Human MARK4-1198H Recombinant Human MARK4 Protein (N44-K370), Tag Free E.coli No tag N44-K370
Mouse MARK4-9570M Recombinant Mouse MARK4 Protein Mammalian Cell His
Mouse MARK4-5375M Recombinant Mouse MARK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MARK4-5375M-B Recombinant Mouse MARK4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MARK4 Related Articles
  • MARK4 Related Signal Pathway

MARK4 involved in several pathways and played different roles in them. We selected most pathways MARK4 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, LKB1 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Anchoring of the basal body to the plasma membraneTCTN3;ODF2;MKS1;AKAP9;TUBB4A;DYNC1I2;NEDD1;MAPRE1A;CENPJ
Assembly of the primary ciliumEXOC8;CEP78;IFT46;ODF2B;MKS1;TTC30B;ARL13B;CP110;RP2
LKB1 signaling eventsSTK11IP;MARK2;MARK4;CTSD;CDC37;MAP2;SIK3
Organelle biogenesis and maintenanceUNC119B;BBS12;BBS2;OST4;GFM2;FLR;CCDC123;TMEM67;MRPS26

MARK4 has several biochemical functions, for example, ATP binding, gamma-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK4 itself. We selected most functions MARK4 had, and list some proteins which have the same functions with MARK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingEPHB2;ABCA8;UBE2D2;EIF2AK4;TPK1;ATP9A;DHX32A;CHTF18;GART
gamma-tubulin bindingMARK4;DIXDC1;TUBGCP2;NDRG1;B9D2;PDE4B;FEZ1;OFD1;CEP57L1
microtubule bindingARL3;KIF17;VAPA;NDEL1;PRC1B;AKAP1;RCC2;CDK5RAP2;RAB11A
protein bindingRAB3A;POU5F1;BPTF;RAI1;C1GALT1C1;KCNA3;NOL11;PMAIP1;SMC2
protein serine/threonine kinase activityDCKL1B;CAMK2G1;PLK1;PRKCBB;CLK3;TNK2;CAMK2B1;MAP4K2;RPS6KA2
tau-protein kinase activityPRKAA1;CSNK1D;GSK3A;GSK3B;PHKG1;PHKG2;MARK1;CDK5;MARK2
ubiquitin bindingUCHL1;UBXN2B;UBAP1;TSG101;VPS28;NSFL1C;TRP53INP2;FAN1;BRAP

MARK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK4.

YWHAH; TUBG1; STK11; PRKCI; CDC42; PNMA1; PRNP; MAPT

Houde, VP; Ritorto, MS; et al. Investigation of LKB1 Ser(431) phosphorylation and Cys(433) farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. BIOCHEMICAL JOURNAL 458:41-56(2014).
Gu, GJ; Lund, H; et al. Role of Individual MARK Isoforms in Phosphorylation of Tau at Ser(262) in Alzheimer's Disease. NEUROMOLECULAR MEDICINE 15:458-469(2013).
Magnani, I; Novielli, C; et al. Multiple localization of endogenous MARK4L protein in human glioma. CELLULAR ONCOLOGY 31:357-370(2009).
Moroni, RF; De Biasi, S; et al. Distinct expression pattern of microtubule-associated protein/microtubule affinity-regulating kinase 4 in differentiated neurons. NEUROSCIENCE 143:83-94(2006).
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