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Official Full Name melanocortin 3 receptor
Background This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
Synonyms MC3R; melanocortin 3 receptor; MC3; OB20; OQTL; BMIQ9; MC3-R; melanocortin receptor 3; obesity quantitative trait locus;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MC3R-772H Recombinant Human MC3R, GST-tagged E.coli GST
    Mouse MC3R-9616M Recombinant Mouse MC3R Protein Mammalian Cell His
    Rat MC3R-3609R Recombinant Rat MC3R Protein Mammalian Cell His
    Zebrafish MC3R-9614Z Recombinant Zebrafish MC3R Mammalian Cell His
    Kit-1032 Total Polyamine Assay Kit (Fluorometric) N/A
    Kit-1372 MC3R Total GPCR Internalization Assay Kit N/A
    Kit-1373 cAMP MC3R CHO-K1 GPCR Assay Kit N/A
    Kit-1374 MC3R U2OS β-Arrestin GPCR Assay Kit N/A

    mc3r involved in several pathways and played different roles in them. We selected most pathways mc3r participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with mc3r were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction TAAR13B; FPR1; DRD4A; GALR3; TAAR14A; GZMA; P2RX3A; NPY8BR; S1PR3; HTR2CL1

    mc3r has several biochemical functions, for example, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by mc3r itself. We selected most functions mc3r had, and list some proteins which have the same functions with mc3r. You can find most of the proteins on our site.

    Function Related Protein
    melanocortin receptor activity MC4R; MC5RB; MC2R; MC5RA; MC1R; MC3R; MC5R
    melanocyte-stimulating hormone receptor activity MC3R; MC1R; MC4R
    neuropeptide binding OPRL1; PTGDR2; MC4R; NPBWR2; NPY8AR; MC3R; SSTR1; MRGPRB1; SSTR4; NPY8BR
    peptide hormone binding CRHR2; MAS1; AGTR1B; GHRHR; INHBA; RXFP2; PTH1RB; NPR1; MC3R; GCGR
    protein binding RPL11; ERP29; DDL-2; FLI1; FASTKD5; FEM1B; NDUFA9; KCTD13; EMP1; PIP5K1A

    mc3r has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mc3r here. Most of them are supplied by our site. Hope this information will be useful for your research of mc3r.


    Peter, JC; Zipfel, G; et al. Antibodies raised against different extracellular loops of the melanocortin-3 receptor affect energy balance and autonomic function in rats. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 30:444-453(2010).
    Getting, SJ; Lam, CW; et al. [D-Trp(8)]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). MOLECULAR PHARMACOLOGY 70:1850-1855(2006).

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