med15
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  • Official Full Name
  • mediator complex subunit 15
  • Background
  • The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • MED15; mediator complex subunit 15; PC2 (positive cofactor 2, multiprotein complex) glutamine/Q rich associated protein , PCQAP, TNRC7, trinucleotide repeat containing 7; mediator of RNA polymerase II transcription subunit 15; Arc105; CAG7A; TIG 1; Activator-recruited cofactor 105 kDa component; CTG repeat protein 7a; CTG7A; PC2 glutamine/Q-rich-associated protein; Positive cofactor 2 glutamine/Q-rich-associated protein; TIG-1; TIG1; TPA-inducible gene 1 protein; OTTHUMP00000198544; OTTHUMP00000198545; OTTHUMP00000198546; OTTHUMP00000198567; TPA inducible gene-1; TPA inducible protein; trinucleotide repeat containin; PCQAP; TNRC7
Cat.#:MED15-4478HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED15 Protein, GST-tagged
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Cat.#:MED15-12302ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED15
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Cat.#:MED15-4392HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MED15 293 Cell Lysate
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Involved Pathway

MED15 involved in several pathways and played different roles in them. We selected most pathways MED15 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
ANK2B; MED20; NR5A1; EPHA10; DPYSL3; MED6; HIF3A; TRIO; PLXNC1; DUSP2
Fatty acid, triacylglycerol, and ketone body metabolism
CPT1B; G0S2; ACAD11; ACSF2; ACSF3; YAP1; CYP7A1; MED22; AGPAT6; ACOT11A
Gene Expression
ZNF3; TNPO1; DDX6; SAP130; ZNF473; ZNF317; TEAD1A; METTL3; LBH; ZNF621
Generic Transcription Pathway
ZNF625; ZNF354A; ZNF302; ESRRG; NR2F6A; SESN3; TBX5; ZNF764; ZNF333; MED16
Metabolism
BCHE; NUDT1; CYP4F11; B3GAT2; CTGF; APOBB.1; Alb; CYP2D6; ACSM1; CPNE6
Metabolism of lipids and lipoproteins
FA2H; SLC44A5B; PHOSPHO1; ARSF; ACOT12; FAAH2; ACOT10; CHKA; ECI1; CYP2U1
PPARA activates gene expression
MED7; MED26; GLIPR1; PLIN2; ANKRD1; MED16; CDK19; MED19; MED9; MTF1
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
PLIN2; MTF1; MED31; MED29; MED16; CDK19; MED15; MED10; GLIPR1; GRHL1

Protein Function

MED15 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED15 itself. We selected most functions MED15 had, and list some proteins which have the same functions with MED15. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription cofactor activity
Related Protein PPARGC1B; MED22; MED19; MED13B; MED19A; MED20; MED4; MDT-19; MED10; MED26
Function protein binding
Related Protein LAMP1; NFKBIA; GTF2A2; RECQL; PSMD11; LARP4B; CYB561; ZNF843; FAIM; ARL8A

Interacting Protein

MED15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED15 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED15.
CDK8; SREBF1; MED10; CDK19; MED19; MED26