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MGAT4B

Official Full Name

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
Background

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
Synonyms

MGAT4B; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B; mannosyl (alpha 1,3 ) glycoprotein beta 1,4 N acetylglucosaminyltransferase, isoenzyme B; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; GnT Ivb; Alpha 1 3 mannosyl glycoprotein beta 1 4 N acetylglucosaminyltransferase; Aminyltransferase; GlcNAc T IVb; GNT IV; GNTIV; GNTIVB; Mannosyl (alpha 1 3) glycoprotein beta 1 4 N acetylglucosaminyltransferase isozyme B; MGAT 4B; N acetylglucosaminyltransferase IVb; N glycosyl oligosaccharide glycoprotein; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase IVb; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IV; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IVb; glcNAc-T IVb; N-acetylglucosaminyltransferase IVb; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; GNT-IV; GNT-IVB;

Type:
Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species :
Human
Mouse
Rhesus Macaque
Zebrafish

Source :
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag :
GST
His
His (Fc)
Avi
N/A
N
6×His, GFP

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MGAT4B-6228HF	Recombinant Full Length Human MGAT4B Protein, GST-tagged	In Vitro Cell Free System	GST	Inquiry
Human	MGAT4B-4341HCL	Recombinant Human MGAT4B 293 Cell Lysate	HEK293	N/A	Inquiry
Human	MGAT4B-06H	Recombinant Human MGAT4B Protein (AA 41-548), N-6×His/GFP tagged	HEK293	N-6×His, GFP	Inquiry
Human	MGAT4B-4365H	Recombinant Human MGAT4B Protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	MGAT4B-5535M-B	Recombinant Mouse MGAT4B Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	MGAT4B-5535M	Recombinant Mouse MGAT4B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Mouse	MGAT4B-9811M	Recombinant Mouse MGAT4B Protein	Mammalian Cell	His	Inquiry
Rhesus Macaque	MGAT4B-2582R	Recombinant Rhesus Macaque MGAT4B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Rhesus Macaque	MGAT4B-2761R	Recombinant Rhesus monkey MGAT4B Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	MGAT4B-2582R-B	Recombinant Rhesus Macaque MGAT4B Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	MGAT4B-399Z	Recombinant Zebrafish MGAT4B	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

MGAT4B involved in several pathways and played different roles in them. We selected most pathways MGAT4B participated on our site, such as Asparagine N-linked glycosylation, Metabolic pathways, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Asparagine N-linked glycosylation	ST6GALNAC2;USO1;TFG;MLEC;PPP6R3;TRAPPC2;MPDU1;PPP6C;ST3GAL3A
Metabolic pathways	ENO1A;GCSHB;ARSB;XYLB;FUT3;GCNT4A;NDUFS2;ENO1;NT5E
Metabolism of proteins	FURINA;GPR120;EEF1G;KDELR3;SEMG1;CNIH3;SENP5;CPE;B3GNT2A
N-Glycan antennae elongation	ST8SIA3;MGAT4A;MGAT4B;ST8SIA2
N-Glycan biosynthesis	FUT8A;B4GALT1;ZNF408;MGAT3A;MAN2A2;ALG3;MGAT4B;MGAT4A;B4GALT2
N-glycan antennae elongation in the medial/trans-Golgi	ST8SIA3;ST8SIA2;MGAT4A;MGAT4B
Post-translational protein modification	PREB;SAE1;MUC13;MPDU1A;MUC20;MPDU1;GALNT6;CNIH3;MUCL1
Transport to the Golgi and subsequent modification	TRAPPC6BL;CTAGE5;PPP6R3;MCFD2;SCFD1;MGAT4A;CNIH2;TRAPPC2;TRAPPC1

MGAT4B has several biochemical functions, for example, alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT4B itself. We selected most functions MGAT4B had, and list some proteins which have the same functions with MGAT4B. You can find most of the proteins on our site.

Function	Related Protein
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	MGAT4B;MGAT4A;MGAT4C;4931440L10Rik
metal ion binding	PDE7A;NR1D4A;ZNF598;Car8;CSH2;KLF6A;FIZ1;NOS2A;NR5A1B

MGAT4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT4B here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT4B.

LRSAM1; bgaB