• Official Full Name

    mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B

  • Overview

    This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
  • Synonyms

    MGAT4B; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B; mannosyl (alpha 1,3 ) glycoprotein beta 1,4 N acetylglucosaminyltransferase, isoenzyme B; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; GnT Ivb; Alpha 1 3 mannosyl glycoprotein beta 1 4 N acetylglucosaminyltransferase; Aminyltransferase; GlcNAc T IVb; GNT IV; GNTIV; GNTIVB; Mannosyl (alpha 1 3) glycoprotein beta 1 4 N acetylglucosaminyltransferase isozyme B; MGAT 4B; N acetylglucosaminyltransferase IVb; N glycosyl oligosaccharide glycoprotein; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase IVb; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IV; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IVb; glcNAc-T IVb; N-acetylglucosaminyltransferase IVb; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; GNT-IV; GNT-IVB;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • 6×His, GFP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MGAT4B-4341HCL Recombinant Human MGAT4B 293 Cell Lysate HEK293 N/A
Human MGAT4B-6228HF Recombinant Full Length Human MGAT4B Protein, GST-tagged In Vitro Cell Free System GST 563 amino acids
Human MGAT4B-4365H Recombinant Human MGAT4B Protein, GST-tagged Wheat Germ GST
Human MGAT4B-06H Recombinant Human MGAT4B Protein (AA 41-548), N-6×His/GFP tagged HEK293 N-6×His, GFP AA 41-548
Mouse MGAT4B-9811M Recombinant Mouse MGAT4B Protein Mammalian Cell His
Mouse MGAT4B-5535M-B Recombinant Mouse MGAT4B Protein Pre-coupled Magnetic Beads HEK293
Mouse MGAT4B-5535M Recombinant Mouse MGAT4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MGAT4B-2761R Recombinant Rhesus monkey MGAT4B Protein, His-tagged Mammalian Cell His
Rhesus Macaque MGAT4B-2582R Recombinant Rhesus Macaque MGAT4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MGAT4B-2582R-B Recombinant Rhesus Macaque MGAT4B Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MGAT4B-399Z Recombinant Zebrafish MGAT4B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MGAT4B involved in several pathways and played different roles in them. We selected most pathways MGAT4B participated on our site, such as Asparagine N-linked glycosylation, Metabolic pathways, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationMCFD2;ANKRD28;CNIH2;TMED2;TRAPPC10;SEC22A;NEU4;CNIH;TRAPPC2
Metabolic pathwaysFUT7;GCNT4A;ALDH3A1;ATP6V0C;PCK1;CYP2B6;ADH1C;CYP19A1A;FUT9
Metabolism of proteinsSLC30A8;O3far1;KLHDC3;NEU3;B3GNT8;GPR119;TBCE;EIF5A;PPP6C
N-Glycan antennae elongationMGAT4B;ST8SIA2;MGAT4A;ST8SIA3
N-Glycan biosynthesisGANAB;MAN1B1;B4GALT1;DPM2;ALG13;TUSC3;MAN1A1;ALG11;DPAGT1
N-glycan antennae elongation in the medial/trans-GolgiMGAT4B;ST8SIA2;MGAT4A;ST8SIA3
Post-translational protein modificationPHC1;ST6GAL2B;ATPBD4;BET1;ADAMTS18;SEC22A;TRAPPC3;OTOP2;B3GNT6
Transport to the Golgi and subsequent modificationTRAPPC6A;MGAT4A;PPP6R1;SEC22C;NAPB;TRAPPC2;PPP6C;NAPG;TRAPPC2L

MGAT4B has several biochemical functions, for example, alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT4B itself. We selected most functions MGAT4B had, and list some proteins which have the same functions with MGAT4B. You can find most of the proteins on our site.

Function Related Protein
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activityMGAT4A;4931440L10Rik;MGAT4C;MGAT4B
metal ion bindingPRKD2;KCNH7;TRIM67;BSN;ZSWIM4;RAD50;ZC3H12A;ZFP750;ZNF330

MGAT4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT4B here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT4B.

LRSAM1; bgaB

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