• Official Full Name

    mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B

  • Background

    This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
  • Synonyms

    MGAT4B; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B; mannosyl (alpha 1,3 ) glycoprotein beta 1,4 N acetylglucosaminyltransferase, isoenzyme B; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; GnT Ivb; Alpha 1 3 mannosyl glycoprotein beta 1 4 N acetylglucosaminyltransferase; Aminyltransferase; GlcNAc T IVb; GNT IV; GNTIV; GNTIVB; Mannosyl (alpha 1 3) glycoprotein beta 1 4 N acetylglucosaminyltransferase isozyme B; MGAT 4B; N acetylglucosaminyltransferase IVb; N glycosyl oligosaccharide glycoprotein; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase IVb; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IV; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IVb; glcNAc-T IVb; N-acetylglucosaminyltransferase IVb; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; GNT-IV; GNT-IVB;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    • N
    • 6×His, GFP
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MGAT4B-6228HF Recombinant Full Length Human MGAT4B Protein, GST-tagged In Vitro Cell Free System GST
    Human MGAT4B-4341HCL Recombinant Human MGAT4B 293 Cell Lysate HEK293 N/A
    Human MGAT4B-06H Recombinant Human MGAT4B Protein (AA 41-548), N-6×His/GFP tagged HEK293 N-6×His, GFP
    Human MGAT4B-4365H Recombinant Human MGAT4B Protein, GST-tagged Wheat Germ GST
    Mouse MGAT4B-5535M-B Recombinant Mouse MGAT4B Protein Pre-coupled Magnetic Beads HEK293
    Mouse MGAT4B-5535M Recombinant Mouse MGAT4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse MGAT4B-9811M Recombinant Mouse MGAT4B Protein Mammalian Cell His
    Rhesus Macaque MGAT4B-2582R Recombinant Rhesus Macaque MGAT4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque MGAT4B-2761R Recombinant Rhesus monkey MGAT4B Protein, His-tagged Mammalian Cell His
    Rhesus Macaque MGAT4B-2582R-B Recombinant Rhesus Macaque MGAT4B Protein Pre-coupled Magnetic Beads HEK293
    Zebrafish MGAT4B-399Z Recombinant Zebrafish MGAT4B Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    MGAT4B involved in several pathways and played different roles in them. We selected most pathways MGAT4B participated on our site, such as Asparagine N-linked glycosylation, Metabolic pathways, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Asparagine N-linked glycosylationST6GALNAC2;USO1;TFG;MLEC;PPP6R3;TRAPPC2;MPDU1;PPP6C;ST3GAL3A
    Metabolism of proteinsFURINA;GPR120;EEF1G;KDELR3;SEMG1;CNIH3;SENP5;CPE;B3GNT2A
    N-Glycan antennae elongationST8SIA3;MGAT4A;MGAT4B;ST8SIA2
    N-Glycan biosynthesisFUT8A;B4GALT1;ZNF408;MGAT3A;MAN2A2;ALG3;MGAT4B;MGAT4A;B4GALT2
    N-glycan antennae elongation in the medial/trans-GolgiST8SIA3;ST8SIA2;MGAT4A;MGAT4B
    Post-translational protein modificationPREB;SAE1;MUC13;MPDU1A;MUC20;MPDU1;GALNT6;CNIH3;MUCL1
    Transport to the Golgi and subsequent modificationTRAPPC6BL;CTAGE5;PPP6R3;MCFD2;SCFD1;MGAT4A;CNIH2;TRAPPC2;TRAPPC1

    MGAT4B has several biochemical functions, for example, alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT4B itself. We selected most functions MGAT4B had, and list some proteins which have the same functions with MGAT4B. You can find most of the proteins on our site.

    Function Related Protein
    alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activityMGAT4B;MGAT4A;MGAT4C;4931440L10Rik
    metal ion bindingPDE7A;NR1D4A;ZNF598;Car8;CSH2;KLF6A;FIZ1;NOS2A;NR5A1B

    MGAT4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT4B here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT4B.

    LRSAM1; bgaB

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