MKL1

  • Official Full Name

    megakaryoblastic leukemia (translocation) 1
  • Overview

    MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.
  • Synonyms

    MKL1;megakaryoblastic leukemia (translocation) 1;MKL/myocardin-like protein 1;basic;SAP and coiled coil domain;BSAC;KIAA1438;MAL;megakaryocytic acute leukemia;MRTF A;myocardin related transcription factor A;basic, SAP and coiled-coil domain;me
Cat.# Product name Source (Host) Species Tag Protein Length Price
MKL1-893H Recombinant Human MKL1, GST-tagged E.coli Human GST 392-741aa
MKL1-9861M Recombinant Mouse MKL1 Protein Mammalian Cells Mouse His
MKL1-1153H Recombinant Human MKL1 protein, His-KSI-tagged E.coli Human His&KSI 400-500aa
MKL1-5572M Recombinant Mouse MKL1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MKL1-5572M-B Recombinant Mouse MKL1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MKL1 involved in several pathways and played different roles in them. We selected most pathways MKL1 participated on our site, such as RHO GTPase Effectors,RHO GTPases Activate Formins,RhoA signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by Rho GTPases ARHGAP17,ARHGAP8,FMNL2,ARHGAP6,STARD8,ARHGAP19,NOXO1A,FAM13A,GDI1,PLEKHG2
    Signal Transduction ROPN1,ARHGAP12B,CNR2,STRA6,GAL,WWOX,NPHP4,NPSR1,RLN3,AKR1C6
    RhoA signaling pathway DIAPH1,CYR61,ACTA1
    RHO GTPases Activate Formins CLIP1,SPDL1,NDEL1B,SPC25,RHOC,RCC2,KNTC1,DSN1,MKL1B,RHOAE
    RHO GTPase Effectors ZWILCH,DIAPH1,ZWINT,ABI1B,SKA1,CIT,WASF3,ABI2,ABI1,ACTR2B

    Protein Function

    MKL1 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity,actin binding,actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKL1 itself. We selected most functions MKL1 had, and list some proteins which have the same functions with MKL1. You can find most of the proteins on our site.

    Function Related Protein
    transcription regulatory region sequence-specific DNA binding NFE2L2,NFE2L2A,CRY2,EPAS1B,NR5A1B,NONO,NFE2L1A,NFE2L2B,HIF1AL,POU5F1
    transcription coactivator activity TADA2A,YY1,ATXN7L3,SP4,PRRX1,AIP,PER2,SMARCE1,JUN,JUP
    actin monomer binding PRKCE,KLHL8,TMSB4X,MYL2,COBLL1,PFN4,CORO1A,COBL,TWF1,TMSB15B
    leucine zipper domain binding ATF4,NRL,PMF1,AATF,KCNA3,DDIT3,ERC1,PAWR,CRX,DAPK3
    actin binding LRRK2,LCP1,CAPGB,CFL2,VMHC,KLHL33,CAPZA1B,MSNB,MSRB2,CNN3A
    RNA polymerase II transcription coactivator activity PSIP1,SMARCA4,MED12L,SMARCA2,PRRX1,POU3F1,ISL1,CITED4,CREBBP,ANKRD1
    protein binding LRP1,BAI2,KLK5,CLN6,NPC2,RTDR1,MYOZ1,SOX4,ZC3H15,PKD2
    transcription factor activity, sequence-specific DNA binding SPI1A,TFDP2,CREBBP,PRDM2,FOXD3,TCF7,PRDM1A,ZNF215,CNBP,RUNX3

    Interacting Protein

    MKL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKL1.

    SRF;MKL2;frwC;MYC

    Resources

    References

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