MKL1
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Official Full Name
megakaryoblastic leukemia (translocation) 1 -
Overview
MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene. -
Synonyms
MKL1;megakaryoblastic leukemia (translocation) 1;MKL/myocardin-like protein 1;basic;SAP and coiled coil domain;BSAC;KIAA1438;MAL;megakaryocytic acute leukemia;MRTF A;myocardin related transcription factor A;basic, SAP and coiled-coil domain;me
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MKL1-893H | Recombinant Human MKL1, GST-tagged | E.coli | Human | GST | 392-741aa | |
| MKL1-9861M | Recombinant Mouse MKL1 Protein | Mammalian Cells | Mouse | His |
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| MKL1-1153H | Recombinant Human MKL1 protein, His-KSI-tagged | E.coli | Human | His&KSI | 400-500aa |
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| MKL1-5572M | Recombinant Mouse MKL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MKL1-5572M-B | Recombinant Mouse MKL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MKL1 involved in several pathways and played different roles in them. We selected most pathways MKL1 participated on our site, such as RHO GTPase Effectors,RHO GTPases Activate Formins,RhoA signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RHO GTPases Activate Formins | RANGAP1B,AHCTF1,RHOAE,DIAPH1,RHOC,FMNL1,SKA2,ZWINT,ZWILCH,SPDL1 |
| RHO GTPase Effectors | NDEL1B,MKL1B,ROPN1,RHPN1,CCDC99,WIPF2,WIPF3,CIT,ABI1,NOXO1A |
| RhoA signaling pathway | ACTA1,DIAPH1,CYR61 |
| Signaling by Rho GTPases | ARHGAP40,MKL1B,ARHGAP23,ARHGAP28,FGD4,RHOT1A,ARHGAP44,RHOT1B,STARD8,RHOV |
| Signal Transduction | MYO7AA,PROKR1A,TLE2,SCUBE2,INSL5,S1PR5B,ABR,UTS2,PROKR2,PRC1B |
Protein Function
MKL1 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity,actin binding,actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKL1 itself. We selected most functions MKL1 had, and list some proteins which have the same functions with MKL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | Aff1,ZNF606,PPARA,HES1,NEUROD2,DMRT2,FOXI1,RORCB,ZFP518A,STAT3 |
| transcription coactivator activity | SMARCC2,CCAR1,GABPA,UTF1,TADA3,GRIP1,PARK7,PRRX1,RARA,CBFB |
| leucine zipper domain binding | AATF,PAWR,CRX,KCNA3,NRL,DDIT3,ERC1,PMF1,DAPK3,ATF4 |
| protein binding | PGLS,USP33,SDHB,ADAP1,ELMO1,RFX1,TNS3,ZFP746,EAF1,FSHR |
| actin binding | PLEKHH2,WASH,LIMCH1,SPATA31,MYO1H,PAWR,MYBPC1,XIRP1,PARVA,AFAP1 |
| actin monomer binding | PFN2,TWF2,ABL2,TMSB,TMSB15B,LIMA1,TMSB10,LMOD3,TMSB4X,PFN4 |
| RNA polymerase II transcription coactivator activity | MYOCD,MKL1B,SOX12,PSIP1,MED12,TFAP2B,NCOA1,ISL1,PRRX1,CITED4 |
| transcription regulatory region sequence-specific DNA binding | NR5A5,BTBD8,CRY2,NFE2L1,PSPC1,NFE2L2,ARNTL1A,NKX3,SOX12,GATA3 |
Interacting Protein
MKL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKL1.
SRF;MKL2;frwC;MYC
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