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Official Full Name myeloid/lymphoid or mixed-lineage leukemia 1
Background Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL (ALL1) gene. MLL stands for Myeloid/Lymphoid, or Mixed-Lineage, Leukemia.
Synonyms Mll1; myeloid/lymphoid or mixed-lineage leukemia 1; HRX; Mll; All1; ALL-1; Cxxc7; HTRX1; KMT2A; mKIAA4050; 6430520K01
    • Species :
    • Mouse
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse MLL1-9881M Recombinant Mouse MLL1 Protein Mammalian Cell His
    Kit-1781 MLL1 Complex Chemiluminescent Assay Kit N/A
    Kit-1977 MLL1 SAM-Screener Assay Kit N/A

    mll1 involved in several pathways and played different roles in them. We selected most pathways mll1 participated on our site, such as Lysine degradation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with mll1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysine degradation COLGALT2; GLT25D2; ACAT2; DOT1L; EHMT1B; C2orf34; SETD7; SUV39H1; ALDH3A2A; SETDB1
    Transcriptional misregulation in cancer Itgam&Itgb2; JMJD1C; TCF3; RXRA; CCNT1; IL1R2; IGF1; NUPR1; MET; DDX5

    mll1 has several biochemical functions, for example, DNA binding, chromatin binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by mll1 itself. We selected most functions mll1 had, and list some proteins which have the same functions with mll1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding GSX2; TERF1; PAX4; MESP1; H3F3B.1; HIST2H2AA2; ZNF547; ARID5B; GZF1; SSBP3B
    chromatin binding PKN1; ZKSCAN3; KDM6B; SNAI2; PPARG; SMC3; ELK4; ORC1L; BEND6; MEIS3
    core promoter sequence-specific DNA binding SOX1; SP1; PDX1; SOHLH2; NFYA; ESR1; THRAP3; PROX1; NR4A3; ZFHX3
    histone methyltransferase activity (H3-K4 specific) KMT2A; KMT2E; WBP7; SETMAR; WDR82; ASH1L; SETD3; MLL1; SMYD1B; WHSC1L1
    histone-lysine N-methyltransferase activity SUV39H1; WBP7; SETD8A; SETDB1B; MLL1; EHMT1; SMYD1; WHSC1L1; KMT2A; SMYD2B
    identical protein binding SSNA1; TNPO3; BAG2; LRP6; MMP9; HOMER1; HSPB1; CASC3; FBXW7; GOT1
    lysine-acetylated histone binding TAF1; ATAD2B; BRD7; BRD2; BRD3; SMARCA4; CARM1; BAZ1B; PHIP; PSME4
    metal ion binding DNAJA2; CTDSP1; PAPOLG; DRL; CYP1D1; Car2; AGAP2; PLA2G4D; FOXP1; NCALDB
    methyltransferase activity SMYD2A; METTL21D; FTSJD2; PRMT1; NSUN6; PRDM1; PRDM15; SUV39H1B; METTL10; PRMT5
    protein binding TMEM100; ADAMTSL3; PRPSAP1; ZBTB8A; ENOX2; ROR1; PDCL3; SMARCA2; IRF3; TBCD
    protein homodimerization activity TBX15; BAXA; NADK2; Trl; PDGFRA; GREM2; FGFR1; C9orf142; TLR13; ZBTB1
    transcription regulatory region DNA binding IKZF2; TP63; ARID4A; ZFP513; FOS; TFAP2A; KLF17; TAF2; NR1D1; MZF1
    transferase activity PLAUB; UGT5F1; BSK146; JAK2B; ST3GAL5L; ELOVL7A; CKMT2A; ST3GAL2L; STK24B; MGAT1B
    unmethylated CpG binding KDM2A; CXXC1; MLL1; DNMT3A; DNMT3B
    zinc ion binding ADAM10; SHRPRBCK1R; CPDB; CXXC5; MMP15; PIAS4A; TRIM12A; ZFAND3; NR2E1; FHL1

    mll1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mll1 here. Most of them are supplied by our site. Hope this information will be useful for your research of mll1.

    siglecg_mouse_gene; Rbbp5

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