| Description : |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His |
| Molecular Mass : |
30.6 kDa |
| Protein length : |
18-267 |
| Purity : |
>95% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB). |
| Applications : |
ELISA, Western Blot, Antibody Production, Protein array |
| Quality Control Test : |
10% SDS-PAGE stained with Coomassie Blue (CB), immunoblotting with anti-6xHis (WB) and peptide fingerprinting by MALDI-TOF-TOF mass spectrometry. |
| Storage : |
Store working aliquots at 4 centigrade for up to one week. For extended storage, conserve at −80 centigrade. |
| Expiry : |
12 months from the date of purchase, if it is properly stored. |
| Storage Buffer : |
20mM Tris-HCl, 0.5M NaCl, 1mM 2-mercaptoethanol, 0.2M Imidazole, pH:8.0. No preservatives added. |
| Shipping : |
Dry Ice |
