Recombinant Human MMP7 Protein, GST-tagged

• Cat.No.: MMP7-5435H
• Product Overview: Human MMP7 full-length ORF ( NP_002414.1, 1 a.a. - 267 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 56.1 kDa
• AA Sequence: MRLTVLCAVCLLPGSLALPLPQEAG GMSELQWEQAQDYLKRFYLYDSETK NANSLEAKLKEMQKFFGLPITGMLN SRVIEIMQKPRCGVPDVAEYSLFPN SPKWTSKVVTYRIVSYTRDLPHITV DRLVSKALNMWGKEIPLHFRKVVWG TADIMIGFARGAHGDSYPFDGPGNT LAHAFAPGTGLGGDAHFDEDERWTD GSSLGINFLYAATHELGHSLGMGHS SDPNAVMYPTYGNGDPQNFKLSQDD IKGIQKLYGKRSNSRKK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MMP7 matrix metallopeptidase 7 (matrilysin, uterine) [ Homo sapiens ]
• Official Symbol: MMP7
• Synonyms: MMP7; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7 (matrilysin, uterine) , MPSL1; matrilysin; PUMP 1; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine); MMP-7; MPSL1; PUMP-1
• Gene ID: 4316
• mRNA Refseq: NM_002423
• Protein Refseq: NP_002414
• MIM: 178990
• UniProt ID: P09237