Recombinant Rat Mmp7 protein, His & T7-tagged

• Cat.No.: Mmp7-749R
• Product Overview: Recombinant Rat Mmp7 aa. (Met1~Leu267 (Accession # P50280)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Rat
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 33.4kDa
• Protein length: Met1~Leu267 (Accession # P50280)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 8.7.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Mmp7 matrix metallopeptidase 7 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Mmp7
• Synonyms: MPMM; MMP-7; Matrix metalloproteinase 7 (matrilysin); matrin; matrix metalloproteinase-7; pump-1 protease; uterine metalloproteinase; matrilysin
• Gene ID: 25335
• mRNA Refseq: NM_012864.2
• Protein Refseq: NP_036996.1
• UniProt ID: P50280

Reviews

05/01/2023

This includes rigorous quality control measures to ensure the consistency and purity of the protein, thereby reducing variability in the experimental outcomes.

05/13/2022

by utilizing MMP7 protein in trials and collaborating with a supportive manufacturer, researchers can gain access to a versatile tool that can aid in their understanding of angiogenesis and vascular biology.

05/26/2018

With expert assistance and reliable product quality, researchers can conduct their experiments with confidence, enabling them to contribute to advancements in the field and potentially improve future therapeutic interventions.

Q&As

What clinical conditions are associated with MMP7 overexpression?

MMP7 overexpression has been linked to various diseases, including cancer, inflammatory disorders, and tissue fibrosis.

In what ways does MMP7 contribute to inflammatory processes?

MMP7 is involved in the degradation of extracellular matrix components during inflammation, influencing tissue damage and repair processes.

How can MMP7 be targeted for therapeutic interventions?

Developing specific inhibitors that target MMP7 activity is a potential approach for therapeutic interventions, particularly in diseases where MMP7 plays a detrimental role.

Are there any inhibitors developed for MMP7?

Several MMP inhibitors have been investigated, and some show promise in controlling MMP7 activity. However, their clinical use is still under research.

How is MMP7 involved in cancer progression?

MMP7 facilitates cancer cell invasion and metastasis by degrading the extracellular matrix, allowing cancer cells to invade surrounding tissues and spread to distant organs.

Can MMP7 be used as a biomarker for cancer diagnosis?

Yes, elevated levels of MMP7 have been observed in the serum or tissues of cancer patients, making it a potential biomarker for certain types of cancer.