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MRPL15

Official Full Name

mitochondrial ribosomal protein L15
Overview

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q.
Synonyms

MRPL15; mitochondrial ribosomal protein L15; 39S ribosomal protein L15, mitochondrial; HSPC145; L15mt; MRP L7; MRP L15; RPML7; 39S ribosomal protein L15; 39S ribosomal protein L15 mitochondrial; MRPL 15; RPML 7; OTTHUMP00000226445; OTTHUMP00000226575; MRP-L7; MRP-L15;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRPL15-982H	Recombinant Human MRPL15, His-tagged	E.coli	His	1-296aa	$319 / 25μg
Human	MRPL15-4194HCL	Recombinant Human MRPL15 293 Cell Lysate	HEK293	Non		Inquiry
Human	MRPL15-5559H	Recombinant Human MRPL15 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MRPL15-6385HF	Recombinant Full Length Human MRPL15 Protein, GST-tagged	In Vitro Cell Free System	GST	296 amino acids	Inquiry
Mouse	MRPL15-10047M	Recombinant Mouse MRPL15 Protein	Mammalian Cell	His		Inquiry
Mouse	MRPL15-5688M	Recombinant Mouse MRPL15 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	MRPL15-5688M-B	Recombinant Mouse MRPL15 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MRPL15-885Z	Recombinant Zebrafish MRPL15	Mammalian Cell	His		Inquiry
Chicken	MRPL15-1530C	Recombinant Chicken MRPL15	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MRPL15 involved in several pathways and played different roles in them. We selected most pathways MRPL15 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome	RPS12;RPS4Y2;RPL23A;RPL24;RPL31;RPS4Y1;RPL36;RPL41;MRPL15

MRPL15 has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL15 itself. We selected most functions MRPL15 had, and list some proteins which have the same functions with MRPL15. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	PKM2;SSRP1;C14orf93;SRP54B;HSPA9;UBE2N;RPS2;SUPT5H;MRPS28
protein binding	RSAD2;TIPRL;L3MBTL4;NCALD;THAP11;SCARB1;AARSD1;PIP;ALPI
structural constituent of ribosome	RPL11;MRPL47;RPL13;MRPL49;MRPL42;MRPL13;MRPL34;RPL36A;RPS6

MRPL15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL15 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL15.

CCNDBP1; RUNDC3A; ssrna_ug; Zfp36; YBX1; ICT1; NOP9; SLX4; MRPL50; MRPL9; MRPL1

Research Area

Koc, EC; Burkhart, W; et al. The large subunit of the mammalian mitochondrial ribosome - Analysis of the complement of ribosomal proteins present. JOURNAL OF BIOLOGICAL CHEMISTRY 276:43958-43969(2001).