MTMR2
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Official Full Name
myotubularin related protein 2
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Overview
This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. -
Synonyms
MTMR2; myotubularin related protein 2; CMT4B; myotubularin-related protein 2; KIAA1073; CMT4B1; MTMR2_HUMAN; OTTHUMP00000204445; OTTHUMP00000204446; OTTHUMP00000204447; OTTHUMP00000204448;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
MTMR2 involved in several pathways and played different roles in them. We selected most pathways MTMR2 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTMR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | MTMR4;PTENA;PIP5K1BB;INPP5B;PIP4K2A;MTMR7B;INPP4B;ITPKA;PIP5K1AA |
| Metabolic pathways | UGT1AB;PIP5K1AA;CYP21A2;B3GNT5;HYKK.2;UPB1;BDH2;PLA2G1B;NME3 |
| Phosphatidylinositol signaling system | PLCD1;CALM4;MTMR7A;IMPA2;PLCG1;PLCB1;SYNJ2;PI4KB;IMPA1 |
MTMR2 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTMR2 itself. We selected most functions MTMR2 had, and list some proteins which have the same functions with MTMR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | MTMR2;CTDSPL2A;MTMR8;MTMR1A;SACM1LA;CTDSPL2B;MTMR1;MTM1;SGPP2 |
| phosphatidylinositol-3-phosphatase activity | SACM1L;MTMR14;PTEN;MTMR1B;MTM1;MTMR1;MTMR1A;FIG4;MTMR8 |
| protein binding | ATG7;ZBTB49;IFT20;DNAJB9;TBCEL;EPN2;ZG16;GET4;C20orf20 |
| protein homodimerization activity | SLC24A6;PYGL;NOS2;BOKA;HSP90AA1;CHKA;PAFAH1B2;SMAD3;GSTM4 |
| protein tyrosine phosphatase activity | DUSP16;DUSP21;MTMR1;PTPN11B;DUSP8A;CDC14C;CDKN3;CDC25C;DUSP26 |
| protein tyrosine/serine/threonine phosphatase activity | DUSP18;DUSP9;SACM1L;DUSP13;PTP4A1;PTPDC1;PTEN;DUSP21;CDC14C |
MTMR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTMR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTMR2.
NEFL; MTMR12; q7ard3_yerpe; tcaA1; metQ
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