MTPAP
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Official Full Name
mitochondrial poly(A) polymerase -
Overview
The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3 poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011] -
Synonyms
MTPAP;mitochondrial poly(A) polymerase;PAPD1;SPAX4;poly(A) RNA polymerase, mitochondrial;TUTase 1;terminal uridylyltransferase 1;polynucleotide adenylyltransferase;PAP-associated domain-containing protein 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MTPAP-10216M | Recombinant Mouse MTPAP Protein | Mammalian Cells | Mouse | His |
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| MTPAP-1280HCL | Recombinant Human MTPAP cell lysate | Human | Non |
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| MTPAP-5793M | Recombinant Mouse MTPAP Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MTPAP-5793M-B | Recombinant Mouse MTPAP Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MTPAP involved in several pathways and played different roles in them. We selected most pathways MTPAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MTPAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MTPAP has several biochemical functions, for example, ATP binding,UTP binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTPAP itself. We selected most functions MTPAP had, and list some proteins which have the same functions with MTPAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | BST2,TBL2,HOXB6,C4BPA,RPL23A,FCF1,HIST1H4C,LSM14A,GLTSCR2,YTHDC1 |
| UTP binding | HSP90AB1 |
| magnesium ion binding | PGM1,DOM3Z,TOP2A,COMTA,NEK6,STK11,RPS6KA2,MARK2,NUDT16,TSSK6 |
| polynucleotide adenylyltransferase activity | PAPD4,PAPOLB,PAPD7,TUT1,PAPOLA,PAPOLG |
| ATP binding | NIM1K,TGFBR1A,RIPK3,KIF20A,DNAJA3B,ALDH18A1,KIF3A,MAP2K4,BBS10,KIF7 |
| identical protein binding | SH3BP4,CLDN20,HOOK2,LECT2,APLP2,PAFAH1B3,EGFR,ETNPPL,RNF4,NFKBIA |
| manganese ion binding | FAM20C,MPPE1,PPEF2,WRN,PIM1,PPM1B,NUDT7,HMGCL,B4GALT7,NPEPL1 |
| protein homodimerization activity | MAP3K12,PCYT1A,DMRT2A,ADH1,IDE,GM5506,NR0B1,CADM3,ZHX2,GRM6 |
| protein binding | CIB2,STAMBP,TRIM17,ACY1,KLRC1,SH3BP4,RINT1,MAPT,KLK5,FERD3L |
Interacting Protein
MTPAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTPAP here. Most of them are supplied by our site. Hope this information will be useful for your research of MTPAP.
CALCOCO2;Azi2;TBK1;Dynll1;NPM1;RPL10;DYNLL1;ICT1
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References
- Roberge, S; Roussel, J; et al. TNF-alpha-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes. CARDIOVASCULAR RESEARCH 103:90-99(2014).
- Sirisha, VL; Sinha, M; et al. Menadione-induced caspase-dependent programmed cell death in the green chlorophyte Chlamydomonas reinhardtii. JOURNAL OF PHYCOLOGY 50:587-601(2014).
