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MXD4

Official Full Name

MAX dimerization protein 4
Overview

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
Synonyms

MXD4; MAX dimerization protein 4; bHLHc12; MAD4; MST149; MSTP149; MAD 4; Mad4 homolog; Max associated protein 4; Max interacting transcriptional repressor MAD4; MST 149; MSTP 149; MXD 4; max dimerizer 4; OTTHUMP00000115253; max-associated protein 4; class C basic helix-loop-helix protein 12; max-interacting transcriptional repressor MAD4;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human

Source

E.coli
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MXD4-1119H	Recombinant Human MXD4, GST-tagged	E.coli	GST	1-209aa	$319 / 25ug
Human	MXD4-569H	Recombinant Human MXD4 Protein, His-tagged	E.coli	His		Inquiry
Human	MXD4-1157HCL	Recombinant Human MXD4 cell lysate		N/A		Inquiry
Human	MXD4-5776H	Recombinant Human MXD4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MXD4-6634HF	Recombinant Full Length Human MXD4 Protein, GST-tagged	In Vitro Cell Free System	GST	58 amino acids	Inquiry
Chicken	MXD4-1599C	Recombinant Chicken MXD4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MXD4 involved in several pathways and played different roles in them. We selected most pathways MXD4 participated on our site, such as Validated targets of C-MYC transcriptional repression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MXD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Validated targets of C-MYC transcriptional repression	TMEFF2;CSDE1;MXD4;GFI1;TMEM126A;S100A7;CLU;NDRG1;SFXN3

MXD4 has several biochemical functions, for example, DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MXD4 itself. We selected most functions MXD4 had, and list some proteins which have the same functions with MXD4. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	MYO18A;ZFP523;FOXM1;ZNF593;ENG2B;TNP1;KDM5D;MAFBB;ISX
protein binding	ASF1B;ILK;MAT2B;SMN2;RCOR2;ADAMTSL5;EEA1;PLEKHB2;CHD1
protein dimerization activity	HEY1;GPR139;TFE3B;ATOH8;ASCL5;HER15.1;MITFA;HER5;HER2
transcription corepressor activity	PROX1;E2F8;ATF3;DNMT3B;CCAR1;BHLHE40;WNT4;CDYL;DAXX

MXD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MXD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MXD4.

TCP10L; Max; Trappc11