ncor2

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ncor2

Official Full Name nuclear receptor corepressor 2
Background SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.
Synonyms NCOR2; nuclear receptor corepressor 2; nuclear receptor co repressor 2; CTG26; SMRT; SMRTE; TNRC14; TRAC 1; CTG repeat protein 26; T3 receptor-associating factor; thyroid-, retinoic-acid-receptor-associated corepressor; silencing mediator for retinoid and thyroid hormone receptors; TRAC; TRAC1; N-CoR2; TRAC-1; SMAP270; SMRTE-tau; FLJ25011
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NCOR2-1889H Recombinant Human Nuclear Receptor Corepressor 2, GST-tagged E.coli GST
    Zebrafish NCOR2-1619Z Recombinant Zebrafish NCOR2 Mammalian Cell His
    Kit-0618 NCOR2 Gene Knockdown Quantification Kit N/A

    ncor2 involved in several pathways and played different roles in them. We selected most pathways ncor2 participated on our site, such as Notch signaling pathway, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ncor2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway NOTCH1B; HDAC1; APH1C; DTX2; DLC; NUMB; JAG1A; DVL1B; JAG2B; MAML2
    Epstein-Barr virus infection PIK3R1; NEDD4; PIK3R3; HLA-DQA1; IFNG; RELA; PRKACA; TRAF5; PIK3CD; HDAC5

    ncor2 has several biochemical functions, for example, DNA binding, Notch binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ncor2 itself. We selected most functions ncor2 had, and list some proteins which have the same functions with ncor2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding CSDC2; MLXIPL; GLI4; PRDM9; HOXB3A; ABT1; HELZ2; MBD3B; POLR2A; ZFP513
    Notch binding DLL3; NOTCH1; JAG2B; EGFL7; HIF1AN; CHAC1; NOTCH4; DNER; JAG1A; DLL4
    histone deacetylase binding MAGEA1; MEF2D; TCF21; NRIP1; HDAC4; HDAC6; TRAF6; MAGEA2B; GLI3; D7ERTD443E
    ligand-dependent nuclear receptor binding NCOA2; TADA3; JUND; TRIP4; ISL1; TRIM24; NCOR1; C1D; SMARCD3; PPARGC1A
    protein N-terminus binding DCTN4; LACRT; STX5A; SLC6A3; EIF3E; SMARCE1; TAF11; NCOA1; RPA3; PHB2
    protein binding TRAPPC6A; PSME3; ANO6; POR; BATF; CDKN2A; EPM2A; GPBP1; TFR2; CST2
    transcription corepressor activity CTCF; TRIM28; APEX1; CDX2; RYBP; ATN1; SSX2; TBL1XR1; DNMT3B; PPP1R13L
    transcription factor binding SMARCD3; DOT1L; SMAD2; NFIA; PPRC1; HTT; APBB3; MAFB; KCTD1; PAX6

    ncor2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ncor2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ncor2.

    Carlberg, C; Dunlop, TW; et al. The impact of chromatin organization of vitamin D target genes. ANTICANCER RESEARCH 26:2637-2645(2006).
    Widerak, M; Ghoneim, C; et al. The aryl hydrocarbon receptor activates the retinoic acid receptor alpha through SMRT antagonism. BIOCHIMIE 88:387-397(2006).

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