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NEK3

Official Full Name

NIMA (never in mitosis gene a)-related kinase 3
Overview

This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

NEK3; NIMA (never in mitosis gene a)-related kinase 3; serine/threonine-protein kinase Nek3; glycogen synthase A kinase; HSPK36; hydroxyalkyl protein kinase; MGC29949; phosphorylase B kinase kinase; serine/threonine protein kinase NEK3; HSPK 36; hydroxyal;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Human
Mouse

Source

Insect (sf21)
Insect Cell
Sf21
Sf9 Insect Cell

Tag

GST
GST|His
His
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NEK3-116HFL	Active Recombinant Full Length Human NEK3 Protein, N-His-tagged	Sf21	His	Full Length	Inquiry
Human	NEK3-29620TH	Recombinant Human NEK3		N/A		Inquiry
Human	NEK3-369H	Recombinant Human NEK3, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	NEK3-7074HF	Active Recombinant Full Length Human NEK3 Protein, GST-tagged	Insect (sf21)	GST	1-506	Inquiry
Mouse	NEK3-924M	Active Recombinant Mouse NEK3 Protein, GST & His-tagged	Insect Cell	GST/His		Inquiry
Mouse	NEK3-446MCL	Recombinant Mouse NEK3 cell lysate	Insect Cell	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NEK3 involved in several pathways and played different roles in them. We selected most pathways NEK3 participated on our site, such as Prolactin Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Prolactin Signaling Pathway	SHC3;SOCS6;STAT3;MAPK9;IRF1;STAT5A;RELA;CCND2;PIK3R1

NEK3 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK3 itself. We selected most functions NEK3 had, and list some proteins which have the same functions with NEK3. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	BCKDK;MYO6;UBE2S;INO80;AGAP2;PDIK1L;CHD8;FICD;CSNK1DB
metal ion binding	CAR13;METAP2;ADNP2A;MOB2;CTDSPL;ZNF563;ZCCHC16;CAPN8;ZFPM2
protein binding	RAB3IL1;EIF3D;CSNK1G1;ISG20L2;ALS2CR11;TMPRSS15;BANP;WHRN;POLL
protein serine/threonine kinase activity	PDPK1;GM711;TP53RK;CHEK2;CAMK2A;PRKCD;NEK8;PRKCA;RPS6KA1

NEK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK3.

PRLR; VAV2; BPGM; CDCA8; NMNAT1