NFATC4

Official Full Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Overview

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Synonyms

NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; NFAT3; NF-AT3; NF-ATC4; nuclear factor of activated T-cells, cytoplasmic 4; T-cell transcription factor NFAT3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFATC4-1275H	Recombinant Human NFATC4, GST-tagged	E.coli	GST	228-582aa	$319 / 25μg
Human	NFATC4-1188HCL	Recombinant Human NFATC4 cell lysate		Non		Inquiry
Human	NFATC4-750H	Recombinant Human NFATC4 Protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Mouse	NFATC4-10613M	Recombinant Mouse NFATC4 Protein	Mammalian Cell	His		Inquiry
Mouse	Nfatc4-4390M	Recombinant Mouse Nfatc4 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	NFATC4-6031M	Recombinant Mouse NFATC4 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	NFATC4-6031M-B	Recombinant Mouse NFATC4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
NFATC4 Related Signal Pathway

NFATC4 involved in several pathways and played different roles in them. We selected most pathways NFATC4 participated on our site, such as cGMP-PKG signaling pathway, Wnt signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	RAF1;VDAC1;KCNJ8;VDAC2;MEF2A;AKT1;ATF4;CREB3L3;PIK3R3
Wnt signaling pathway	NFATC1;DKK2;CTNNBIP1;RBX1;LRP5;FZD1;WNT3;NKD2;PRKCBB
Axon guidance	SDCBP;ARPC4;SPTBN1;ABLIM2;AGRN;PLXNA1;SEMA4A;JAK3;PEA15A
Oxytocin signaling pathway	CACNG4;MYL6B;MYL6;PPP3CA;GNAI2;MEF2C;PLCB4;PRKACB;PLCB2
Hepatitis B	CASP10;CCNE1;CREB3L1;NFATC1;TRP53;TLR4;CYCS;IFNA12;STAT5A
HTLV-I infection	DVL3;FOS;Fzd4;HLA-DOA;IL1R1;ITGB2;WNT6;HLA-DMB;ETS1

NFATC4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, peroxisome proliferator activated receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC4 itself. We selected most functions NFATC4 had, and list some proteins which have the same functions with NFATC4. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NKX6;TFE3;FOXJ2;RUNX2;JUNBB;TFAM;NACC2;ZNF562;GMEB2
peroxisome proliferator activated receptor binding	IKBKG;ASXL2;PPARGC1A;MED1;EP300;NR0B2;HMGA1;CREBBP;HMGA1-RS1
protein binding	EIF4EBP2;APTX;GJA1;CSTF1;RC3H2;NUP205;C11orf67;MALSU1;USF2
transcription coactivator activity	HSF2;ABT1;TFDP1A;NR1I3;HTATIP2;MMS19;JMY;TADA3;TFDP1B
transcription factor binding	FIGLA;SMAD2;FOXO1;BCOR;DRG1;ARRB1;PIAS1;MAPK1;PURB
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	PYDC3;TCF21;YY1;GATA3;MXD1;NFIL3-4;NFATC2;ATF3;E2F8

NFATC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC4.

UBC; Dlg4; PASK; MAPK14; NR1I2; JUP; CCNG1; GPR22; ANKRD28; YWHAQ

Research Area

Petra, H; Eva, H; et al. Molecular Profiling of Acute and Chronic Rejections of Renal Allografts. CLINICAL & DEVELOPMENTAL IMMUNOLOGY :-(2013).

Minematsu, H; Shin, MJ; et al. Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. CELLULAR SIGNALLING 23:1785-1793(2011).