Recombinant Human NFKB1 protein, GST-tagged

• Cat.No.: NFKB1-3742H
• Product Overview: Recombinant Human NFKB1 protein(1-368 aa), fused to GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
• Protein length: 1-368 aa
• AA Sequence: MAEDDPYLGRPEQMFHLDPSLTHTI FNPEVFQPQMALPTADGPYLQILEQ PKQRGFRFRYVCEGPSHGGLPGASS EKNKKSYPQVKICNYVGPAKVIVQL VTNGKNIHLHAHSLVGKHCEDGICT VTAGPKDMVVGFANLGILHVTKKKV FETLEARMTEACIRGYNPGLLVHPD LAYLQAEGGGDRQLGDREKELIRQA ALQQTKEMDLSVVRLMFTAFLPDST GSFTRRLEPVVSDAIYDSKAPNASN LKIVRMDRTAGCVTGGEEIYLLCDK VQKDDIQIRFYEEEENGGVWEGFGD FSPTDVHRQFAIVFKTPKYKDINIT KPASVFVQLRRKSDLETSEPKPFLY YPEIKDKEEVQRKRQKLM
• Purity: 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [ Homo sapiens ]
• Official Symbol: NFKB1
• Synonyms: NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor NF-kappa-B p105 subunit; KBF1; NF kappaB; NF kB1; NFkappaB; NFKB p50; p50; p105; NF-kappabeta; DNA binding factor KBF1; DNA-binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit; EBP-1; NF-kB1; NFKB-p50; NF-kappaB; NFKB-p105; NF-kappa-B; MGC54151; DKFZp686C01211
• Gene ID: 4790
• mRNA Refseq: NM_001165412
• Protein Refseq: NP_001158884
• MIM: 164011
• UniProt ID: P19838

Reviews

06/16/2022

Potent biological activity of NFKB1, combined with its high purity, provides accurate and reliable experimental data for the research field.

04/22/2022

The short half-life and high clearance of NFKB1 allow its rapid action and rapid clearance in vivo, improving therapeutic efficiency.

05/21/2019

Beacuse production process of NFKB1 realizes the minimization of waste and the minimal impact on the environment, which is truly green production.

Q&As

What is the role of NFKB1 protein in autoimmune diseases?

NFKB1 protein is involved in the occurrence and progression of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

What is the relationship between NFKB1 protein and apoptosis?

NFKB1 protein plays a complex role in apoptosis and may promote or inhibit the occurrence of apoptosis.

What drugs interact with the NFKB1 protein?

A variety of drugs have been developed that target the NFKB1 protein and its downstream signaling pathways, such as inhibiting NFKB1 activation or inhibiting the transcriptional activity of NFKB1 downstream genes.

Does the NFKB1 protein study have implications for new drug development?

The protein plays a key role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of NFKB1 protein will help the development of new drugs, such as targeted drugs targeting NFKB1 protein and its signaling pathway may be applied to the treatment of related diseases.

Is there a potential application of NFKB1 protein in the design of immune vaccines?

This protein plays an important role in the activation of immune cells and the regulation of inflammation, so it can be used in immune vaccine design to enhance immune effects.

Why does NFKB1 protein have a pattern of expression in immune cells?

The expression pattern of NFKB1 protein in immune cells is regulated by different stimuli and environments, and participates in the activation and regulation of immune cells.