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NR5A1

  • Official Full Name

    nuclear receptor subfamily 5, group A, member 1

  • Overview

    The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]
  • Synonyms

    NR5A1; nuclear receptor subfamily 5, group A, member 1; ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3; steroidogenic factor 1; STF-1; nuclear receptor AdBP4; steroidogenic factor-1; adrenal 4 binding protein; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1 nuclear receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NR5A1-31465TH Recombinant Human NR5A1 Wheat Germ N/A 461 amino acids
Human NR5A1-1361H Recombinant Human NR5A1, His-tagged E.coli His 1-349aa
Human NR5A1-368H Recombinant Human NR5A1 Mammalian Cell His
Human NR5A1-3705HCL Recombinant Human NR5A1 293 Cell Lysate HEK293 N/A
Human NR5A1-4436H Recombinant Human NR5A1 protein, His-tagged E.coli His 218-461aa
Human NR5A1-6099H Recombinant Human NR5A1 Protein, GST-tagged Wheat Germ GST
Human NR5A1-2435H Recombinant Human NR5A1 protein, His&Myc-tagged E.coli His&Myc 1-461aa
Human NR5A1-3675H-B Recombinant Human NR5A1 Protein Pre-coupled Magnetic Beads HEK293
Human NR5A1-6746HF Recombinant Full Length Human NR5A1 Protein, GST-tagged In Vitro Cell Free System GST 461 amino acids
Human NR5A1-3675H Recombinant Human NR5A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NR5A1-10874M Recombinant Mouse NR5A1 Protein Mammalian Cell His
Mouse NR5A1-6191M-B Recombinant Mouse NR5A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse NR5A1-6191M Recombinant Mouse NR5A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nr5a1-2386M Recombinant Mouse Nr5a1 protein, His-tagged E.coli His 1-462aa
Rat NR5A1-4073R Recombinant Rat NR5A1 Protein Mammalian Cell His
Rat NR5A1-3732R Recombinant Rat NR5A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NR5A1-3732R-B Recombinant Rat NR5A1 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL18363HF Recombinant Full Length Human Steroidogenic Factor 1(Nr5A1) Protein, His&Myc-Tagged E.coli expression system His&Myc Full Length (1-461aa)
Mus musculus (Mouse) RFL34153MF Recombinant Full Length Mouse Steroidogenic Factor 1(Nr5A1) Protein, His-Tagged E.coli expression system His Full Length (1-462aa)
Chicken NR5A1-6634C Recombinant Chicken NR5A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NR5A1 Related Articles

NR5A1 involved in several pathways and played different roles in them. We selected most pathways NR5A1 participated on our site, such as Developmental Biology, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyPLXNC1;FGF18B;STX1B;COL6A3;BOC;MED29;EVL;FRS2B;ACVR1C
Gene ExpressionZNF12;AIMP2;ZNF599;ZNF688;SNAPC3;ZNF45;NR1I2;CD3EAP;METTL1
Generic Transcription PathwayZNF215;ZNF615;PRDM7;SKIA;ZNF567;ZNF692;ZNF729;ZNF563;ZNF45
Nuclear Receptor transcription pathwayNR2F6;ESR2B;RORAA;NR2F6B;NR5A1;ESRRGA;RXRBB;NR5A1B;NR0B1
Nuclear ReceptorsNR5A1;VDRB;NR1D2;NR2F2;NR2E1;RARGA;NR2C2;NR2F6;NR1H3
Ovarian Infertility GenesZP2;DAZL;NRIP1;NR5A1;GJA4;MSH5;SYNE2;INHA;DMC1
Transcriptional regulation of pluripotent stem cellsNR5A1;HIF3A;POU5F3;TDGF1;PRDM14;LIN28A;NR6A1;SALL4;FOXD3
Wnt Signaling Pathway NetPathTAX1BP3;SOX1;PAX2;HIPK2;BCL9;TCF4;CRYBB2;TFAP2A;ANKRD6

NR5A1 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A1 itself. We selected most functions NR5A1 had, and list some proteins which have the same functions with NR5A1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingBHLHA15;TGIF2LY;PTGES2;VENT;SP1;EHF;HIST1H47;ZFP526;RBFOX3
RNA polymerase II distal enhancer sequence-specific DNA bindingSOX10;ESRRB;NONO;NFKB1;H2AFZ;CDX1;RXRB;POU4F1;SFPI1
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingNR6A1;ESRRB;NR2F6B;NR4A2B;NR5A2;AHR;NR2E3;NR1I2;PPARD
chromatin bindingNFIA;NSBP1;YBX1;Ar;SMC3;CITED2;FOSL2;JUB;PHF13
enzyme bindingTOP2B;PDCD2;LGALS9;TOP2A;P4HB;CLSTN2;SCARB2;STC2;AKT1
phospholipid bindingESYT1;OSBPL1A;F3;SMURF1;PLA2G7;SYTL4;PACSIN1;BPIFC;Defa4
protein bindingMCM8;GCC1;MSH4;RAD23B;PHF7;CLUAP1;PASK;PRPSAP1;MYD88
steroid hormone receptor activityNR4A1;RXRB;NR2F6B;NR4A2A;ESR2B;NR4A2;RXRBA;VDRA;ESR2A
transcription coactivator activityHCFC2;WNT3A;LPIN3;MED6;TAF1;TAF11;MMS19;KAT2B;HAND1
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingFOXF2A;PAX3;GLI1;TLE4;MITF;PTH;NKX2-5;MEF2C;GATA4
transcription regulatory region sequence-specific DNA bindingNFE2L1A;FOXJ1;NR5A2;PITX2;PSPC1;PER2;SOX4;NFE2L2A;NFE2L1
zinc ion bindingCD4;GATA2;APOBEC3D;LHX1;BMP1A;TRIM7;FBXO30;CNOT4B;UHRF2

NR5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A1.

NCK2; NR0B1; PNRC2; 3bhs2_human_gene; FYN; NCK1; PIK3R1; CRK; GRB2; q7cfn3_yerpe; PROX1; cp11a_human_gene; star_human_gene; SMARCA5

Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).
Sridevi, P; Chaitanya, RK; et al. FTZ-F1 and FOXL2 up-regulate catfish brain aromatase gene transcription by specific binding to the promoter motifs. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1819:57-66(2012).
Yokoyama, C; Komatsu, T; et al. Generation of Rat Monoclonal Antibodies Specific for Ad4BP/SF-1. HYBRIDOMA 28:113-119(2009).
Falender, AE; Lanz, R; et al. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. ENDOCRINOLOGY 144:3598-3610(2003).
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