nr5a1
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  • Official Full Name
  • nuclear receptor subfamily 5, group A, member 1
  • Background
  • The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]
  • Synonyms
  • NR5A1; nuclear receptor subfamily 5, group A, member 1; ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3; steroidogenic factor 1; STF-1; nuclear receptor AdBP4; steroidogenic factor-1; adrenal 4 binding protein; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1 nuclear receptor;
Cat.#:NR5A1-6099HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR5A1 Protein, GST-tagged
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Cat.#:NR5A1-1361HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR5A1, His-tagged
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Cat.#:NR5A1-31465THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NR5A1
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Cat.#:NR5A1-368HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NR5A1
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Cat.#:NR5A1-10874MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NR5A1 Protein
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Cat.#:NR5A1-4073RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR5A1 Protein
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Cat.#:NR5A1-6634CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR5A1
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Cat.#:NR5A1-3705HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR5A1 293 Cell Lysate
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Involved Pathway

NR5A1 involved in several pathways and played different roles in them. We selected most pathways NR5A1 participated on our site, such as Developmental Biology, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
SCN2A; LGI1A; RHOAE; COL9A3; EFNA3; EPHA2; SCN3B; RHOC; RND1L; PAK4
Gene Expression
ZNF222; ZNF398; RRAGA; ZNF454; SPCS3; THG1L; ZNF718; RRN3; MANEA; SLBP
Generic Transcription Pathway
ZNF398; ZNF133; ZNF583; COX7C; ZNF689; ZNF266; ZNF777; COX6A1; ZNF324; RORAA
Nuclear Receptor transcription pathway
NRBF2; NR2F1B; NR4A2B; NR2F6; NR1D2A; NR2F1; RORAA; NR6A1; NR1H3; VDRB
Nuclear Receptors
RARG; NR2F2; NR1D2; RORAA; NR1H3; NR0B1; NR1I3; NR2C2; NR2F1A; RARGA
Ovarian Infertility Genes
NR5A1; ZP3; INHA; NRIP1; ZP2; SYNE2; MSH5; DMC1; GJA4; DAZL
Transcriptional regulation of pluripotent stem cells
NR6A1; PRDM14; SALL4; LIN28A; NR5A1; FOXD3; POU5F3; HIF3A; TDGF1
Wnt Signaling Pathway NetPath
TAX1BP3; ANKRD6; BRD7; TFAP2A; MARK2; NR5A1; BCL9; MTAP1B; PAX2; TCF4

Protein Function

NR5A1 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A1 itself. We selected most functions NR5A1 had, and list some proteins which have the same functions with NR5A1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HOXB5A; NR5A2; MEIOB; HMGB3A; HNF1B; THAP8; XRCC6; SEBOX; SNAPC4; MEF2CB
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein ZBTB16; REL; ARX; PAX4; CDX2; HOXB5; NFKB1; SFPQ; RUVBL2; NR2F6
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR5A2; Ar; RORA; PPARAB; NR2F5; RORB; NR0B1; NR6A1; NR2F6A; RORC
Function chromatin binding
Related Protein PROP1; NOC3L; APTX; NKX2; HDAC4; ESR1; SOX14; LRWD1; GPR30; SP100
Function enzyme binding
Related Protein MDM4; PPP3CB; UGT1A3; CYP2A4; ECM1; RPA2; GSTM7; NKX2-1; LAMP1; CBX1
Function phospholipid binding
Related Protein PACSIN1; PSD2; BAD; CPS1; NBEAA; PLA2G2A; PRKCI; AGAP1; APOM; PLA2G4C
Function protein binding
Related Protein SECISBP2; EIF5B; WASF2; PDPK1; KIF20A; SLC9A3; PTPN7; BRK1; TICAM1; WNK1
Function steroid hormone receptor activity
Related Protein NR5A1A; NR1D2A; VDRA; NR0B1; NR4A3; RXRA; VDR; NR6A1; NR0B2A; NR6A1B
Function transcription coactivator activity
Related Protein APEX1; MED20; TFDP1A; NEUROD1; JMY; NCOA1; MED23; PML; TADA1; SOX10
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein FOXF1; SRY; NR5A1; MYOD1; GLI1; TEAD2; SOX17; POU3F3; MYOG; MEF2A
Function transcription regulatory region sequence-specific DNA binding
Related Protein NFE2L2; NFE2; NONO; NKX3-1; BTBD8; CREB3L3; NFE2L2A; NR5A1A; NR5A1; MKL1
Function zinc ion binding
Related Protein ZFAND4; CA12; TRIM29; RNF187; SEC23B; ZFP326; CIZ1; DPF2; PYGO1; PCGF6

Interacting Protein

NR5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A1.
NCK2; NR0B1; PNRC2; 3bhs2_human_gene; FYN; NCK1; PIK3R1; CRK; GRB2; q7cfn3_yerpe; PROX1; cp11a_human_gene; star_human_gene; SMARCA5

NR5A1 Related Articles

Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).
Sridevi, P; Chaitanya, RK; et al. FTZ-F1 and FOXL2 up-regulate catfish brain aromatase gene transcription by specific binding to the promoter motifs. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1819:57-66(2012).
Yokoyama, C; Komatsu, T; et al. Generation of Rat Monoclonal Antibodies Specific for Ad4BP/SF-1. HYBRIDOMA 28:113-119(2009).
Falender, AE; Lanz, R; et al. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. ENDOCRINOLOGY 144:3598-3610(2003).